Dynamic Alterations of Amplitude of Low-Frequency Fluctuations in Patients With Drug-Naïve First-Episode Early Onset Schizophrenia.
Dynamic Alterations of Amplitude of Low-Frequency Fluctuations in Patients With Drug-Naïve First-Episode Early Onset Schizophrenia.
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DOI：
10.3389/fnins.2020.00901
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发表时间：
2020
影响因子：
4.3
通讯作者：
Xu Y
中科院分区：
文献类型：
--
作者：
Li Q;Cao X;Liu S;Li Z;Wang Y;Cheng L;Yang C;Xu Y
早发型精神分裂症（EOS）的静态神经活动异常已被广泛报道。然而，EOS中随时间推移的动态脑活动变化尚不清楚。在这里，我们调查是否时间动态变化的自发神经活动的EOS的影响。本研究共入组了78例首次用药的EOS患者和90例健康对照（HC）。低频波动的动态幅度（dALFF）检查异常时变的局部神经活动的EOS。此外，我们研究了EOS患者dALFF变异性异常与临床特征之间的关系。与HC相比，EOS患者双侧楔前叶、右侧上级边缘回、右侧中央后回的dALFF变异性显著降低，右侧颞中回（MTG）的dALFF变异性显著增加。此外，MTG的dALFF变异性增加与EOS的阴性症状呈负相关。我们的研究结果揭示了皮质高级网络中动态局部神经活动的增加，这表明自发性大脑活动的增强可能是大脑成熟的主要神经标志。此外，默认模式网络（DMN）和边缘系统中dALFF变异性的降低可能反映了异常的动态神经活动。这种功能失调的脑活动可以区分患者和HC，加深我们对EOS病理生理机制的理解。
Abnormalities in static neural activity have been widely reported in early onset schizophrenia (EOS). However, dynamic brain activity alterations over time in EOS are unclear. Here, we investigated whether temporal dynamic changes in spontaneous neural activity are influenced by EOS. A total of 78 drug-naïve first-episode patients with EOS and 90 healthy controls (HCs) were enrolled in this study. Dynamic amplitude of low-frequency fluctuations (dALFF) was performed to examine the abnormal time-varying local neural activity in EOS. Furthermore, we investigated the relationships between abnormalities in dALFF variability and clinical characteristics in EOS patients. Compared to HCs, EOS patients showed significantly decreased dALFF variability in the bilateral precuneus, right superior marginal gyrus, right post-central gyrus and increased dALFF in the right middle temporal gyrus (MTG). Moreover, increased dALFF variability in MTG was negatively associated with negative symptoms in EOS. Our findings reveal increased dynamic local neural activity in higher order networks of the cortex, suggesting that enhanced spontaneous brain activity may be a predominant neural marker for brain maturation. In addition, decreased dALFF variability in the default mode network (DMN) and limbic system may reflect unusually dynamic neural activity. This dysfunctional brain activity could distinguish between patients and HCs and deepen our understanding of the pathophysiological mechanisms of EOS.
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影响因子：
6.6
作者：
Arsalidou, Marie;Yaple, Zachary;Ushakov, Vadim
通讯作者：
Ushakov, Vadim
影响因子：
5.7
作者：
Hutchison RM;Womelsdorf T;Allen EA;Bandettini PA;Calhoun VD;Corbetta M;Della Penna S;Duyn JH;Glover GH;Gonzalez-Castillo J;Handwerker DA;Keilholz S;Kiviniemi V;Leopold DA;de Pasquale F;Sporns O;Walter M;Chang C
通讯作者：
Chang C
影响因子：
16.2
作者：
Calhoun, Vince D.;Miller, Robyn;Pearlson, Godfrey;Adali, Tulay
通讯作者：
Adali, Tulay
影响因子：
6.6
作者：
Bluhm, Robyn L.;Miller, Jodi;Williamson, Peter
通讯作者：
Williamson, Peter
影响因子：
3.7
作者：
Alcala-Lopez, Daniel;Smallwood, Jonathan;Bzdok, Danilo
通讯作者：
Bzdok, Danilo