Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging.
Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging.
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DOI：
10.1016/j.addr.2009.11.002
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发表时间：
2010-03-08
影响因子：
16.1
通讯作者：
Zhang, Miqin
中科院分区：
文献类型：
--
作者：
Veiseh, Omid;Gunn, Jonathan W.;Zhang, Miqin
关键词：
磁性纳米颗粒（MNP）代表了一类非侵入性成像剂，已开发用于磁共振（MR）成像。这些MNP传统上通过被动靶向用于疾病成像，但最近的进展为这些纳米颗粒的细胞特异性靶向，药物递送和多模式成像打开了大门。随着更精细的MNP的设想，遵守适当的设计标准（例如尺寸，涂层，分子功能化）变得更加重要。本文综述了影响MNP体内性能的设计参数，包括理化性质和纳米颗粒表面修饰，如MNP涂层和靶向配体功能化，可以增强MNP的生物屏障管理。用于修饰的表面的MNP的化学的仔细审查也给出了，注意优化绑定配体的活性，同时保持有利的物理化学性质。
Magnetic nanoparticles (MNPs) represent a class of non-invasive imaging agents that have been developed for magnetic resonance (MR) imaging. These MNPs have traditionally been used for disease imaging via passive targeting, but recent advances have opened the door to cellular-specific targeting, drug delivery, and multi-modal imaging by these nanoparticles. As more elaborate MNPs are envisioned, adherence to proper design criteria (e.g. size, coating, molecular functionalization) becomes even more essential. This review summarizes the design parameters that affect MNP performance in vivo, including the physicochemical properties and nanoparticle surface modifications, such as MNP coating and targeting ligand functionalizations that can enhance MNP management of biological barriers. A careful review of the chemistries used to modify the surfaces of MNPs is also given, with attention paid to optimizing the activity of bound ligands while maintaining favorable physicochemical properties.
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