Plasma NfL is associated with mild cognitive decline in patients with diabetes
Plasma NfL is associated with mild cognitive decline in patients with diabetes
复制标题
血浆 NfL 与糖尿病患者轻度认知能力下降相关
DOI：
10.1111/psyg.12819
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发表时间：
2022
期刊：
影响因子：
2
通讯作者：
Kudo T
中科院分区：
文献类型：
--
作者：
Marutani N;Akamine S;Kanayama D;Gotoh S;Yanagida K;Maruyama R;Mori K;Miyamoto T;Adachi H;Sakagami Y;Yoshiyama K;Hotta M;Nagase A;Kozawa J;Maeda N;Otsuki M;Matsuoka T;Iwahashi H;Shimomura I;Murayama N;Watanabe H;Ikeda M;Mizuta I;Kudo T
背景糖尿病患者认知功能下降的风险更高。因此，需要能够提供认知衰退的早期和简单检测的生物标志物。神经丝轻链（NfL）是构成神经轴突的细胞骨架蛋白。当神经变性发生时，血浆NfL水平升高。在这里，我们调查了血浆NfL水平是否与2型diabetes.MethodThis研究包括183例2型糖尿病患者访问大坂大学医院的认知能力下降。所有参与者均使用简易精神状态检查（MMSE）和Rivermead行为记忆测试（RBMT）进行认知功能测试。NfL水平在血浆中进行了分析，NfL和认知功能之间的关系进行了examined. ResultsLowerRBMT标准化的个人资料评分（SPS）或MMSE评分与较高的血浆NfL水平（单向方差分析：MMSE，P= 0.0237; RBMT-SPS，P= 0.0001）。此外，血浆NfL水平（β = − 0.34，P = 0.0005）和年龄（β = − 0.19，P = 0.016）与多变量回归校正后的RBMT评分显著相关。这表明，血浆NfL水平可能提供了一个有价值的临床工具，用于识别糖尿病患者的轻度认知功能下降。
BackgroundPatients with diabetes are at a higher risk for cognitive decline. Thus, biomarkers that can provide early and simple detection of cognitive decline are required. Neurofilament light chain (NfL) is a cytoskeletal protein that constitutes neural axons. Plasma NfL levels are elevated when neurodegeneration occurs. Here, we investigated whether plasma NfL levels were associated with cognitive decline in patients with type 2 diabetes.MethodThis study included 183 patients with type 2 diabetes who visited Osaka University Hospital. All participants were tested for cognitive function using the Mini‐Mental State Examination (MMSE) and the Rivermead Behavioural Memory Test (RBMT). NfL levels were analysed in the plasma and the relationship between NfL and cognitive function was examined.ResultsLower RBMT‐standardized profile scores (SPS) or MMSE scores correlated with higher plasma NfL levels (one‐way analysis of variance: MMSE,P= 0.0237; RBMT‐SPS,P= 0.0001). Furthermore, plasma NfL levels (β = −0.34,P= 0.0005) and age (β = −0.19,P= 0.016) were significantly associated with the RBMT score after multivariable regression adjustment.ConclusionsPlasma NfL levels were correlated with mild cognitive decline which is detected by the RBMT but not the MMSE in patients with type 2 diabetes. This suggests that plasma NfL levels may provide a valuable clinical tool for identifying mild cognitive decline in patients with diabetes.
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影响因子：
29
作者：
Zetterberg H;Skillbäck T;Mattsson N;Trojanowski JQ;Portelius E;Shaw LM;Weiner MW;Blennow K;Alzheimer’s Disease Neuroimaging Initiative
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
影响因子：
11.2
作者：
Scherling, Carole S.;Hall, Tracey;Berisha, Flora;Klepac, Kristen;Karydas, Anna;Coppola, Giovanni;Kramer, Joel H.;Rabinovici, Gil;Ahlijanian, Michael;Miller, Bruce L.;Seeley, William;Grinberg, Lea T.;Rosen, Howard;Meredith, Jere, Jr.;Boxer, Adam L.
通讯作者：
Boxer, Adam L.
影响因子：
11.1
作者：
Mattsson N;Insel PS;Palmqvist S;Portelius E;Zetterberg H;Weiner M;Blennow K;Hansson O;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
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影响因子：
2.6
作者：
E. Laukka;Sari Jones;B. Small;L. Fratiglioni;L. Bäckman
通讯作者：
L. Bäckman
影响因子：
9.9
作者：
Weston PSJ;Poole T;Ryan NS;Nair A;Liang Y;Macpherson K;Druyeh R;Malone IB;Ahsan RL;Pemberton H;Klimova J;Mead S;Blennow K;Rossor MN;Schott JM;Zetterberg H;Fox NC
通讯作者：
Fox NC