Peptide Self-Assembly for Crafting Functional Biological Materials.
Peptide Self-Assembly for Crafting Functional Biological Materials.
复制标题
用于制作功能生物学材料的肽自组装。
DOI：
10.1016/j.cossms.2011.08.001
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发表时间：
2011-12
影响因子：
11
通讯作者：
Stupp, Samuel I.
中科院分区：
文献类型：
--
作者：
Matson, John B.;Zha, R. Helen;Stupp, Samuel I.
关键词：
自组装肽基支架是寻找在再生医学中具有广泛影响的生物材料的领跑者。肽固有的生物相容性和细胞信号传导能力，结合二级结构的控制，已经导致开发了广泛的功能材料，这些材料具有许多新疗法的潜力。最近，通过肽纳米结构与天然生物聚合物的复合形成的膜已经导致了在生物学和医学中具有潜在深远应用的分层结构构建体的发展。在这篇综述中，我们强调了肽基凝胶和膜的最新进展，包括我们小组和其他人的工作。具体而言，我们讨论了肽基材料在骨和釉质、软骨和中枢神经系统再生中的应用，以及胰岛移植、伤口愈合、心血管治疗和阴茎切除术后勃起功能障碍的治疗
Self-assembling, peptide-based scaffolds are frontrunners in the search for biomaterials with widespread impact in regenerative medicine. The inherent biocompatibility and cell signaling capabilities of peptides, in combination with control of secondary structure, has led to the development of a broad range of functional materials with potential for many novel therapies. More recently, membranes formed through complexation of peptide nanostructures with natural biopolymers have led to the development of hierarchically-structured constructs with potentially far-reaching applications in biology and medicine. In this review, we highlight recent advances in peptide-based gels and membranes, including work from our group and others. Specifically, we discuss the application of peptide-based materials in the regeneration of bone and enamel, cartilage, and the central nervous system, as well as the transplantation of islets, wound-healing, cardiovascular therapies, and treatment of erectile dysfunction after prostatectomy
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