Adaptation in the auditory midbrain of the barn owl (Tyto alba) induced by tonal double stimulation
Adaptation in the auditory midbrain of the barn owl (Tyto alba) induced by tonal double stimulation
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音调双重刺激诱导仓鸮（Tyto alba）听觉中脑的适应
DOI：
10.1111/j.1460-9568.2011.07967.x
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发表时间：
2012
影响因子：
3.4
通讯作者：
Wagner H
中科院分区：
文献类型：
--
作者：
Singheiser M;Ferger R;v. Campenhausen M;Wagner H
在狩猎过程中，仓鸮通常会听到几个连续的声音，比如老鼠的沙沙声。由于听觉细胞表现出适应性编码，早期的刺激可能会影响对后期刺激的检测。用两种双刺激模式模拟了这种情况，并研究了仓鸮下丘中央核神经元的适应性。每个双刺激范式由第一刺激或参考刺激和第二刺激（探针）组成。在一种范式（第二级调节）中，探针水平是变化的，而在另一种范式（刺激间间隔调节）中，第一和第二刺激之间的刺激间隔是系统地改变的。用最佳频率的单耳纯音刺激神经元，并在细胞外记录反应。当参考刺激与探针水平相同且刺激间隔较短时，被试对探针的反应显著降低。这表明响应适应，如果后者处于神经元速率水平函数动态范围的下半部分，则可以通过比参考水平增加5-7 dB的探针水平来补偿。从适应中恢复可以最好地与显示快速（1.25 ms）和缓慢（800 ms）分量的双指数相匹配。这些结果表明，听觉系统中的神经元对音调双重刺激表现出动态编码特性，这可能与忠实的上游信号传播有关。此外，掩蔽物的整体刺激水平似乎也会影响听觉神经元的恢复能力。
During hunting, the barn owl typically listens to several successive sounds as generated, for example, by rustling mice. As auditory cells exhibit adaptive coding, the earlier stimuli may influence the detection of the later stimuli. This situation was mimicked with two double‐stimulus paradigms, and adaptation was investigated in neurons of the barn owl’s central nucleus of the inferior colliculus. Each double‐stimulus paradigm consisted of a first or reference stimulus and a second stimulus (probe). In one paradigm (second level tuning), the probe level was varied, whereas in the other paradigm (inter‐stimulus interval tuning), the stimulus interval between the first and second stimulus was changed systematically. Neurons were stimulated with monaural pure tones at the best frequency, while the response was recorded extracellularly. The responses to the probe were significantly reduced when the reference stimulus and probe had the same level and the inter‐stimulus interval was short. This indicated response adaptation, which could be compensated for by an increase of the probe level of 5–7 dB over the reference level, if the latter was in the lower half of the dynamic range of a neuron’s rate‐level function. Recovery from adaptation could be best fitted with a double exponential showing a fast (1.25 ms) and a slow (800 ms) component. These results suggest that neurons in the auditory system show dynamic coding properties to tonal double stimulation that might be relevant for faithful upstream signal propagation. Furthermore, the overall stimulus level of the masker also seems to affect the recovery capabilities of auditory neurons.
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影响因子：
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作者：
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