Distinct populations of neurons respond to emotional valence and arousal in the human subthalamic nucleus
Distinct populations of neurons respond to emotional valence and arousal in the human subthalamic nucleus
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不同的神经元群体对人类底丘脑核中的情绪价和唤醒做出反应
DOI：
10.1073/pnas.1410709112
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
R. Jech
中科院分区：
文献类型：
--
作者：
T. Sieger;T. Serranová;F. Ruzicka;P. Vostatek;J. Wild;D. Šťastná;C. Bonnet;D. Novák;E. Růžička;D. Urgošík;R. Jech
意义 帕金森病 (PD) 中脑深部刺激的神经精神副作用表明丘脑底核 (STN) 参与情感处理，但缺乏直接证据。在我们的研究中，我们记录了术中向 PD 患者呈现情感图片期间 STN 的单神经元活动。我们发现了两个空间上不同的“情感”神经元群体，它们对刺激的情感维度做出反应：效价（愉快-不愉快）和唤醒（强度）。正如之前所认为的，这两个情感维度背后的神经回路在功能上是分离的。在这里，我们甚至在单个神经元水平上也观察到了分离的情绪处理。这些结果扩展了我们关于 STN 的情绪作用和情绪的神经基础的知识。动物研究和人类深部脑刺激研究都证明丘脑底核（STN）参与动机和情绪过程；然而，尚未在单神经元水平上直接研究该核在处理人类情感中的参与。我们分析了帕金森病 (PD) 患者情感图片呈现期间 STN 术中微记录的神经元放电与随后进行的情绪效价和唤醒的情感评级之间的关系。我们观察到，根据个人评分，17% 的神经元对情绪效价和视觉刺激的唤醒做出反应。一些神经元的活动与情绪效价相关，而不同的神经元对唤醒做出反应。此外，14%的神经元对视觉刺激有反应。我们的结果表明，人类 STN 中存在参与视觉和情感信息处理或传输的神经元，并提供了在单个神经元水平上单独处理效价和唤醒的情感维度的证据。
Significance The involvement of the subthalamic nucleus (STN) in affective processing has been suggested with the appearance of neuropsychiatric side effects of deep brain stimulation in Parkinson’s disease (PD), but direct evidence has been lacking. In our study, we recorded single-neuron activity from the STN during affective picture presentation to PD patients intraoperatively. We discovered two spatially distinct populations of “affective” neurons responding to the emotional dimensions of the stimuli: valence (pleasantness-unpleasantness) and arousal (intensity). As previously believed, neural circuits underlying these two affective dimensions are functionally segregated. Here we observed separated emotional processing even at the single neuron level. These results extend our knowledge regarding the emotional role of the STN and the neural basis of emotions. Both animal studies and studies using deep brain stimulation in humans have demonstrated the involvement of the subthalamic nucleus (STN) in motivational and emotional processes; however, participation of this nucleus in processing human emotion has not been investigated directly at the single-neuron level. We analyzed the relationship between the neuronal firing from intraoperative microrecordings from the STN during affective picture presentation in patients with Parkinson’s disease (PD) and the affective ratings of emotional valence and arousal performed subsequently. We observed that 17% of neurons responded to emotional valence and arousal of visual stimuli according to individual ratings. The activity of some neurons was related to emotional valence, whereas different neurons responded to arousal. In addition, 14% of neurons responded to visual stimuli. Our results suggest the existence of neurons involved in processing or transmission of visual and emotional information in the human STN, and provide evidence of separate processing of the affective dimensions of valence and arousal at the level of single neurons as well.
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