An ERβ agonist induces browning of subcutaneous abdominal fat pad in obese female mice.
An ERβ agonist induces browning of subcutaneous abdominal fat pad in obese female mice.
复制标题
ERβ 激动剂诱导肥胖雌性小鼠皮下腹部脂肪垫褐变
DOI：
10.1038/srep38579
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发表时间：
2016-12-06
影响因子：
4.6
通讯作者：
Gustafsson JÅ
中科院分区：
文献类型：
--
作者：
Miao YF;Su W;Dai YB;Wu WF;Huang B;Barros RP;Nguyen H;Maneix L;Guan YF;Warner M;Gustafsson JÅ
雌激素通过雌激素受体α（ERα）控制脂肪组织的大小、酶活性和激素含量，对代谢和能量稳态发挥多种有益作用。雌激素对交感神经节的作用，这是布朗宁过程中的关键球员，鲜为人知。在本研究中，我们表明，ERβ影响布朗宁的皮下脂肪组织（SAT）通过其对交感神经节和SAT本身的作用。选择性ERβ激动剂LY 3201治疗3天，可诱导1岁肥胖WT和ERα−/−雌性小鼠SAT的布朗宁。布朗宁与交感神经节神经元胞核内ERβ表达增加、SAT和交感神经节神经元内两个神经末梢酪氨酸羟化酶增加以及SAT内β3肾上腺素能受体增加有关。LY 3201对幼龄雌性或雄性小鼠的布朗宁没有影响。在年轻雌性的情况下，布朗宁已经最大，而在雄性中，SAT中的ERβ表达非常少，β3-肾上腺素受体表达非常少。交感神经张力和脂肪细胞对儿茶酚胺反应性的增加揭示了ERβ在控制脂肪组织布朗宁中的新作用。
Estrogen, via estrogen receptor alpha (ERα), exerts several beneficial effects on metabolism and energy homeostasis by controlling size, enzymatic activity and hormonal content of adipose tissue. The actions of estrogen on sympathetic ganglia, which are key players in the browning process, are less well known. In the present study we show that ERβ influences browning of subcutaneous adipose tissue (SAT) via its actions both on sympathetic ganglia and on the SAT itself. A 3-day-treatment with a selective ERβ agonist, LY3201, induced browning of SAT in 1-year-old obese WT and ERα−/− female mice. Browning was associated with increased expression of ERβ in the nuclei of neurons in the sympathetic ganglia, increase in tyrosine hydroxylase in both nerve terminals in the SAT and sympathetic ganglia neurons and an increase of β3-adrenoceptor in the SAT. LY3201 had no effect on browning in young female or male mice. In the case of young females browning was already maximal while in males there was very little expression of ERβ in the SAT and very little expression of the β3-adrenoceptor. The increase in both sympathetic tone and responsiveness of adipocytes to catecholamines reveals a novel role for ERβ in controlling browning of adipose tissue.
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影响因子：
7.7
作者：
Saito M;Okamatsu-Ogura Y;Matsushita M;Watanabe K;Yoneshiro T;Nio-Kobayashi J;Iwanaga T;Miyagawa M;Kameya T;Nakada K;Kawai Y;Tsujisaki M
通讯作者：
Tsujisaki M
影响因子：
--
作者：
SHIMIZU, Y;SAITO, M
通讯作者：
SAITO, M
影响因子：
29
作者：
Martínez de Morentin PB;González-García I;Martins L;Lage R;Fernández-Mallo D;Martínez-Sánchez N;Ruíz-Pino F;Liu J;Morgan DA;Pinilla L;Gallego R;Saha AK;Kalsbeek A;Fliers E;Bisschop PH;Diéguez C;Nogueiras R;Rahmouni K;Tena-Sempere M;López M
通讯作者：
López M
影响因子：
2.7
作者：
Paterni I;Granchi C;Katzenellenbogen JA;Minutolo F
通讯作者：
Minutolo F
影响因子：
2.9
作者：
Roesch, DM
通讯作者：
Roesch, DM