Circadian misalignment is associated with Covid-19 infection.
Circadian misalignment is associated with Covid-19 infection.
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DOI：
10.1016/j.sleep.2022.03.015
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发表时间：
2022-05
期刊：
影响因子：
4.8
通讯作者：
Philip P
中科院分区：
文献类型：
--
作者：
Coelho J;Micoulaud-Franchi JA;Wiet AS;Nguyen D;Taillard J;Philip P
昼夜节律系统有助于调节炎症过程，但迄今为止，对昼夜节律失调作为感染新冠肺炎风险因素的作用研究甚少。本研究的目的是在疑似接触或感染SARS-CoV-2的受试者人群中探索昼夜节律失调（昼夜节律系统的慢性紊乱）与新冠病毒感染风险之间的关系。在2021年冬季无封城期间进行的横断面单中心研究。招募工作在一家新型冠状病毒门诊检测中心进行。纳入18至45岁的受试者，无论他们是否有症状，是否为医护人员，是否接触过COVID-19病例。为了确定社会时差，昼夜节律失调的代理，他们被问及他们通常的睡眠-觉醒行为。在工作日和空闲日探索了睡眠持续时间和睡眠-觉醒时间。社交时差被定义为至少2小时的昼夜节律调整（定义为工作日的睡眠中期与空闲日的睡眠中期之间的差异，睡眠中期为就寝时间和起床时间之间的中位数）。纳入了1014例受试者（采样率：10.8%，39%为男性，平均年龄28 ± 8岁），其中56例受试者为Covid-19阳性（阳性率：5.5%）。两组的平均睡眠持续时间相当（7小时47与7小时49，p = 0.733）。社交时差超过2小时的受试者在Covid-19组中占33.3%，而对照组为20.6%（p = 0.026）。在调整年龄、性别、BMI和工作时间表后，社交时差大于2小时的受试者的测试阳性可能性是工作日和空闲日睡眠-觉醒时间相同的受试者的2.07倍（OR = 2.07，95%CI = [1.12-3.80]，p = 0.024）。昼夜节律失调不仅存在于感染新冠肺炎的受试者中，也可能导致更高的感染可能性。对免疫系统的时间生物学影响或夜间活动期间暴露于社会接触的可能性更高可以解释我们的发现，这需要在未来的大型队列研究中得到证实。规律的睡眠-觉醒时间最终可能成为预防COVID-19感染的目标。
Circadian system contributes to the regulation of inflammatory processes, but the role of circadian misalignment as a risk factor for contracting Covid-19 has up to now been poorly studied. The aim of this study was to explore the relationship between circadian misalignment (chronic disturbance of the circadian system) and the risk of Covid-19 infection in a population of subjects suspected of contact or infection with SARS-CoV-2. Cross-sectional single-center study conducted during a period without lockdown in winter 2021. Recruitment took place in a Covid-19 outpatient testing center. Subjects between 18 and 45 years old were included whether they were symptomatic or not, healthcare workers or not, in contact with a Covid-19 case or not. To determine social jetlag, a proxy of circadian misalignment, they were asked about their usual sleep-wake behaviors. Usual sleep duration and sleep-wake timing were explored on workdays and free days. Social jetlag was defined as at least 2 h shift of circadian alignment (defined as the difference between mid-sleep on workdays and mid-sleep on free days, mid-sleep as the median between bedtime and rise time). One thousand fourteen subjects were included (sampling rate: 10.8%, 39% men, mean age 28 ± 8) with 56 subjects positive for Covid-19 (positivity rate: 5.5%). Usual mean sleep duration was equivalent in both groups (7h47 versus 7h49, p = 0.733). Social jetlag greater than 2 h comprised 33.3% of subjects in the Covid-19 group versus 20.6% in the control group (p = 0.026). After adjustment on age, gender, BMI and work schedules, subjects presenting with social jetlag greater than 2 h had a 2.07-fold higher likelihood to test positive than subjects who had identical sleep-wake timing on workdays and free days (OR = 2.07, 95%CI = [1.12–3.80], p = 0.024). Circadian misalignment not only is present in subjects infected by Covid-19 but could also be responsible for a higher likelihood of being infected. The chronobiological impact on the immune system or a higher likelihood of being exposed to social contacts during nocturnal activities could explain our findings, which need to be confirmed in a future large cohort study. Regular sleep-wake timing could ultimately become a target for preventing Covid-19 infection.
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影响因子：
4.1
作者：
Hirshkowitz, Max;Whiton, Kaitlyn;Hillard, Paula J. Adams
通讯作者：
Hillard, Paula J. Adams
影响因子：
2.9
作者：
Scott, Holly;Biello, Stephany M.;Woods, Heather Cleland
通讯作者：
Woods, Heather Cleland
影响因子：
--
作者：
Pataka A;Kotoulas S;Sakka E;Katsaounou P;Pappa S
通讯作者：
Pappa S
影响因子：
3.5
作者：
Roenneberg, T;Wirz-Justice, A;Merrow, M
通讯作者：
Merrow, M
DOI：
10.5935/1984-0063.20200062
发表时间：
2020-07
期刊：
Sleep science (Sao Paulo, Brazil)
影响因子：
--
作者：
Mello MT;Silva A;Guerreiro RC;da-Silva FR;Esteves AM;Poyares D;Piovezan R;Treptow E;Starling M;Rosa DS;Pires GN;Andersen ML;Tufik S
通讯作者：
Tufik S