Function and clinical significance of circRNAs in solid tumors.
Function and clinical significance of circRNAs in solid tumors.
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CIRCRNA在实体瘤中的功能和临床意义。
DOI：
10.1186/s13045-018-0643-z
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发表时间：
2018-07-31
影响因子：
28.5
通讯作者：
Wu C
中科院分区：
文献类型：
--
作者：
Geng Y;Jiang J;Wu C
环状RNA(CircRNA)是一种新型内源性非编码RNA(NcRNA)。CircRNA在许多生物学过程中调节基因的表达，并参与包括肿瘤在内的各种疾病的发生和发展，这些都是目前研究的重点。随着高通量测序技术的发展，越来越多与肿瘤密切相关的CircRNA被发现。大量研究表明，CircRNAs在多种肿瘤组织和癌旁正常组织中的表达存在显著差异。一些特异性表达的CircRNAs可能成为肿瘤诊断和预后的新的生物标志物。本文简要介绍了CircRNAs的特性、生物发生和功能，并详细讨论了它们与癌症的关系。此外，本文还介绍了CircRNAs的几种研究策略。
Circular RNA (circRNA) is a new type of endogenous non-coding RNAs (ncRNAs). circRNA regulates gene expression in many biological processes, and it also participates in the initiation and development of various diseases, including tumors, which are the focus of present research. With the development of high-throughput sequencing technique, an increasing number of circRNAs closely related to tumors have been discovered. According to numerous studies, there is a significant difference in the expressions of circRNAs among a variety of tumor tissues and para-carcinoma normal tissues. Some specifically expressed circRNAs may potentially serve as new biomarkers for tumor diagnosis and prognosis. This systemic review briefly introduces the characteristics, biogenesis, and functions of circRNAs, as well as discusses their relationship with cancer in detail. In addition, this article also describes several research strategies for circRNAs.
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DOI：
10.12659/msm.908837
发表时间：
2018-03-20
期刊：
Medical science monitor : international medical journal of experimental and clinical research
影响因子：
--
作者：
Cai D;Liu Z;Kong G
通讯作者：
Kong G
影响因子：
4
作者：
Chen G;Shi Y;Zhang Y;Sun J
通讯作者：
Sun J
影响因子：
4.5
作者：
Burd CE;Jeck WR;Liu Y;Sanoff HK;Wang Z;Sharpless NE
通讯作者：
Sharpless NE
圆形RNA电路的多态性和表达模式有助于肝细胞癌的癌变。
影响因子：
--
作者：
Guo W;Zhang J;Zhang D;Cao S;Li G;Zhang S;Wang Z;Wen P;Yang H;Shi X;Pan J;Ye H
通讯作者：
Ye H
影响因子：
4.6
作者：
Bachmayr-Heyda A;Reiner AT;Auer K;Sukhbaatar N;Aust S;Bachleitner-Hofmann T;Mesteri I;Grunt TW;Zeillinger R;Pils D
通讯作者：
Pils D