Associations between locus coeruleus integrity and diagnosis, age, and cognitive performance in older adults with and without late-life depression: An exploratory study.
Associations between locus coeruleus integrity and diagnosis, age, and cognitive performance in older adults with and without late-life depression: An exploratory study.
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DOI：
10.1016/j.nicl.2022.103182
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发表时间：
2022
影响因子：
4.2
通讯作者：
Nikolova, Yuliya S.
中科院分区：
文献类型：
--
作者：
Calarco, Navona;Cassidy, Clifford M.;Selby, Ben;Hawco, Colin;Voineskos, Aristotle N.;Diniz, Breno S.;Nikolova, Yuliya S.
关键词：
半自动分割可以在活体中识别蓝斑的合理结构。蓝斑结构似乎沿其吻尾向范围沿着变化。患有晚年抑郁症的个体显示出完整的蓝斑。老年人蓝斑完整性与认知的多变量分析。老年抑郁症（LLD）是年龄依赖性认知功能衰退的危险因素。蓝斑（LC）中的去甲肾上腺素相关变性可以解释这种联系。为了在体内检查LC去甲肾上腺素系统，我们在48名参与者的样本中获得了神经黑色素敏感的MRI（NM-MRI），其中包括25名LLD（18名女性，年龄68.08 ± 5.41）和23名从未抑郁的对照参与者（ND，12名女性，年龄70 ± 8.02），年龄和认知状态匹配。我们采用了半自动化的程序分割成三个双边部分LC沿着其喙尾的程度，并计算相对对比度作为完整性的代理。然后，我们研究了完整性和LLD诊断，年龄和认知之间的关联，通过可重复电池评估神经心理状态（RBANS）和Delis-Kaplan执行功能系统（D-KEFS）。我们没有发现LLD诊断或年龄对LC完整性的影响，但在合并的参与者样本中进行的探索性典型相关分析显示，完整性和认知之间存在强（Rc = 0.853）和显著的多变量关系（Wilks' λ = 0.03，F（84，162.44）= 1.66，p = <.01）。第一个也是唯一一个显著变量解释了72.83%的模型方差，并将更好的注意力和延迟记忆性能、更快的处理速度和更低的语言流畅性性能与右喙部的更高完整性联系起来，但左尾侧LC的完整性较低。我们的研究结果补充了先前的证据，LC参与健康老年人的认知，并将这种关联扩展到LLD患者。
Semi-automated segmentation can discern plausible locus coeruleus structure in vivo. Locus coeruleus structure appears to vary along its rostrocaudal extent. Individuals with late-life depression show intact locus coeruleus integrity. Multivariate analysis links locus coeruleus integrity and cognition in older adults. Late-life depression (LLD) is a risk factor for age-dependent cognitive deterioration. Norepinephrine-related degeneration in the locus coeruleus (LC) may explain this link. To examine the LC norepinephrine system in vivo, we acquired neuromelanin-sensitive MRI (NM-MRI) in a sample of 48 participants, including 25 with LLD (18 women, age 68.08 ± 5.41) and 23 never-depressed comparison participants (ND, 12 women, age 70 ± 8.02), matched on age and cognitive status. We employed a semi-automated procedure to segment the LC into three bilateral sections along its rostro-caudal extent, and calculated relative contrast as a proxy of integrity. Then, we examined associations between integrity and LLD diagnosis, age, and cognition, as measured via the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Delis-Kaplan Executive Function System (D-KEFS). We did not identify an effect of LLD diagnosis nor age on LC integrity, but exploratory canonical correlation analysis across the combined participant sample revealed a strong (Rc = 0.853) and significant multivariate relationship between integrity and cognition (Wilks’ λ = 0.03, F(84, 162.44) = 1.66, p = <.01). The first and only significant variate explained 72.83% model variance, and linked better attention and delayed memory performance, faster processing speed, and lower verbal fluency performance with higher integrity in the right rostral but lower integrity in the left caudal LC. Our results complement prior evidence of LC involvement in cognition in healthy older adults, and extend this association to individuals with LLD.
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影响因子：
4.2
作者：
Bachman SL;Dahl MJ;Werkle-Bergner M;Düzel S;Forlim CG;Lindenberger U;Kühn S;Mather M
通讯作者：
Mather M
影响因子：
4.7
作者：
Fan Y;Chen P;Li Y;Cui K;Noel DM;Cummins ED;Peterson DJ;Brown RW;Zhu MY
通讯作者：
Zhu MY
影响因子：
8.2
作者：
Cottingham C;Wang Q
通讯作者：
Wang Q
影响因子：
2.5
作者：
CHANPALAY, V;ASAN, E
通讯作者：
ASAN, E
DOI：
10.1073/pnas.1712268115
发表时间：
2018-02-27
影响因子：
11.1
作者：
Hämmerer D;Callaghan MF;Hopkins A;Kosciessa J;Betts M;Cardenas-Blanco A;Kanowski M;Weiskopf N;Dayan P;Dolan RJ;Düzel E
通讯作者：
Düzel E