Symmetric abnormalities in sulcal patterning in schizophrenia.
Symmetric abnormalities in sulcal patterning in schizophrenia.
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DOI：
10.1016/j.neuroimage.2008.07.034
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发表时间：
2008-11-15
期刊：
影响因子：
5.7
通讯作者：
Van Essen DC
中科院分区：
文献类型：
--
作者：
Csernansky JG;Gillespie SK;Dierker DL;Anticevic A;Wang L;Barch DM;Van Essen DC
为了比较精神分裂症患者和非精神分裂症患者大脑皮质的形态及其脑回和脑沟的特征模式，研究人员收集了33名精神分裂症患者和30名在年龄、性别、种族和父母社会经济地位上匹配的健康个体的T1加权磁共振扫描图像，以及临床和认知信息。通过重建每个半球皮质中间厚度（第4层）的表面并将其与人类PALS皮质图谱配准，测量了整个大脑皮质的脑沟深度。使用聚类大小分析和半球间对称性分析方法对脑沟深度的组间差异进行了检验。在双侧顶叶岛盖发现了显著的组间差异，精神分裂症患者的平均脑沟深度较浅。此外，脑沟深度的组间差异在枕叶、顶叶和颞叶皮质的大部分区域显示出显著的双侧对称性。在精神分裂症患者中，左半球的脑沟深度与工作记忆和执行功能测试中表现受损的严重程度相关。
To compare the morphology of the cerebral cortex and its characteristic pattern of gyri and sulci in individuals with and without schizophrenia, T1-weighted magnetic resonance scans were collected, along with clinical and cognitive information, from 33 individuals with schizophrenia and 30 healthy individuals group-matched for age, gender, race and parental socioeconomic status. Sulcal depth was measured across the entire cerebral cortex by reconstructing surfaces of cortical mid-thickness (layer 4) in each hemisphere and registering them to the human PALS cortical atlas. Group differences in sulcal depth were tested using methods for cluster size analysis and interhemispheric symmetry analysis. A significant group difference was found bilaterally in the parietal operculum, where the average sulcal depth was shallower in individuals with schizophrenia. In addition, group differences in sulcal depth showed significant bilateral symmetry across much of the occipital, parietal, and temporal cortices. In individuals with schizophrenia, sulcal depth in the left hemisphere was correlated with the severity of impaired performance on tests of working memory and executive function.
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影响因子：
5.7
作者：
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通讯作者：
Miller, MI
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通讯作者：
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作者：
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影响因子：
17.7
作者：
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通讯作者：
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