Assessment of antioxidant capacity and cytotoxicity of selected Malaysian plants.
Assessment of antioxidant capacity and cytotoxicity of selected Malaysian plants.
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DOI：
10.3390/molecules15042139
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发表时间：
2010-03-25
期刊：
影响因子：
--
通讯作者：
Palanisamy UD
中科院分区：
文献类型：
--
作者：
Ling LT;Radhakrishnan AK;Subramaniam T;Cheng HM;Palanisamy UD
13家马来西亚工厂;对选择用于传统药物的Artocarpus champeden、印楝、草莓x ananassa、山竹、Lawsonia inermis、芒果、Peltophorum pterocarpum、番石榴和Syzygium aqueum进行各种测定。抗氧化能力，总酚含量，元素组成，以及它的细胞毒性，从这些选定的马来西亚植物的不同部分的水和乙醇提取物的几个细胞系进行了测定。在一般情况下，乙醇提取物是更好的自由基清除剂比水提取物和一些测试的提取物甚至比商业葡萄籽制剂更有效。在脂质过氧化抑制研究中观察到类似结果。我们的研究结果还表明，抗氧化活性与总酚含量有很强的相关性。当测试这些提取物的重金属含量时，发现其低于营养应用的允许值。此外，发现大多数提取物在浓度高达100 μg/mL时对3 T3和4 T1细胞没有细胞毒性。我们的结论是，虽然传统上这些植物是用于在水的形式，其商业化的制备可以实现使用乙醇，因为高的总酚含量和抗氧化活性与这种方法的制备。
Thirteen Malaysian plants; Artocarpus champeden, Azadirachta indica, Fragaria x ananassa, Garcinia mangostana, Lawsonia inermis, Mangifera indica, Nephelium lappaceum, Nephelium mutobile, Peltophorum pterocarpum, Psidium guajava and Syzygium aqueum, selected for their use in traditional medicine, were subjected to a variety of assays. Antioxidant capability, total phenolic content, elemental composition, as well as it cytotoxity to several cell lines of the aqueous and ethanolic extracts from different parts of these selected Malaysian plants were determined. In general, the ethanolic extracts were better free radical scavengers than the aqueous extracts and some of the tested extracts were even more potent than a commercial grape seed preparation. Similar results were seen in the lipid peroxidation inhibition studies. Our findings also showed a strong correlation of antioxidant activity with the total phenolic content. These extracts when tested for its heavy metals content, were found to be below permissible value for nutraceutical application. In addition, most of the extracts were found not cytotoxic to 3T3 and 4T1 cells at concentrations as high as 100 μg/mL. We conclude that although traditionally these plants are used in the aqueous form, its commercial preparation could be achieved using ethanol since a high total phenolic content and antioxidant activity is associated with this method of preparation.
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影响因子：
8.8
作者：
Palanisamy, Uma;Ming, Cheng Hwee;Radhakrishnan, Ammu K.
通讯作者：
Radhakrishnan, Ammu K.
影响因子：
6.1
作者：
Vinson, JA;Su, XH;Bose, P
通讯作者：
Bose, P
影响因子：
11.4
作者：
Pinto, Marcia Da Silva;Kwon, Young-In;Shetty, Kalidas
通讯作者：
Shetty, Kalidas
DOI：
10.1111/j.1467-2494.2006.00311.x
发表时间：
2006-04-01
影响因子：
2.3
作者：
Buenger, J.;Ackermann, H.;Wollenweber, U.
通讯作者：
Wollenweber, U.
影响因子：
2.7
作者：
Bose, Anamika;Baral, Rathindranath
通讯作者：
Baral, Rathindranath