Infiltration of alternatively activated macrophages in cancer tissue is associated with MDSC and Th2 polarization in patients with esophageal cancer.
Infiltration of alternatively activated macrophages in cancer tissue is associated with MDSC and Th2 polarization in patients with esophageal cancer.
复制标题
癌组织中选择性活化巨噬细胞的浸润与食管癌患者的 MDSC 和 Th2 极化相关。
DOI：
10.1371/journal.pone.0104453
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Xu H
中科院分区：
文献类型：
--
作者：
Gao J;Wu Y;Su Z;Amoah Barnie P;Jiao Z;Bie Q;Lu L;Wang S;Xu H
骨髓源性抑制细胞（MDSC）在荷癌宿主中扩增并有助于肿瘤免疫逃避。M2巨噬细胞构成癌症相关炎症的主要细胞组分。然而，食管癌患者肿瘤组织中循环MDSC和浸润M2巨噬细胞之间的相关性及其与Th 2细胞极化的潜在关系仍不清楚。本研究发现ECA患者PBMC中MDSC和血浆中Arg 1水平显著升高，且MDSC在PBMC中的比例升高与癌组织中CD 163的表达密切相关。此外，ECA患者外周血IL-4、GATA 3的mRNA水平及IL-13、IL-6的蛋白水平显著升高，而IFN-γ、IL-12水平降低。我们的数据表明，增加的Th 2细胞因子与MDSC和M2巨噬细胞极化相关，并促进CD 163 +M2巨噬细胞在癌组织中的浸润，从而促进ECA患者免疫抑制微环境的形成。
Myeloid derived suppressor cells (MDSCs) expand in cancer bearing hosts and contribute to tumor immune evasion. M2 macrophages constitute a major cellular component of cancer-related inflammation. However, the correlation between circulating MDSCs and infiltrating M2 macrophages in tumor tissues from patients with esophageal cancer (ECA), and its potential relationship with the polarization of Th2 cells remain unclear. In the present study, we showed the level of MDSCs in PBMC and Arg1 in plasma were significantly elevated in ECA patients, and the increased ratio of MDSC in PBMC was closely related to the expression of CD163 in cancer tissues. In addition, the ECA patients exhibited remarkable increases in the mRNA levels of IL-4 and GATA3, as well as the protein levels of IL-13 and IL-6, but IFN-γ and IL-12 in peripheral blood were decreased. Our data indicate that the increased Th2 cytokines are associated with MDSCs and M2 macrophages polarization, and foster the infiltration of CD163+M2 macrophages in cancer tissues, which promote the formation of immunosuppressive microenvironment in ECA patients.
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