Association of human leucocyte antigen phenotype with vaccine efficacy in patients receiving vaginal mucosal immunization for recurrent urinary tract infection.
Association of human leucocyte antigen phenotype with vaccine efficacy in patients receiving vaginal mucosal immunization for recurrent urinary tract infection.
复制标题
接受阴道粘膜免疫治疗复发性尿路感染的患者中人类白细胞抗原表型与疫苗功效的关联。
DOI：
10.1016/s0264-410x(98)00154-6
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发表时间：
1999
期刊：
影响因子：
5.5
通讯作者：
Uehling,DT
中科院分区：
文献类型：
--
作者：
Hopkins,WJ;Heisey,DM;Uehling,DT
Immune responses to specific antigens can be influenced by an individual's genetic make-up. We examined whether the efficacy of a vaginal mucosal vaccine for urinary tract infections (UTI) was affected by a patient's human leucocyte antigen (HLA) phenotype. Urinary tract infection data and the HLA phenotypes of 47 women participating in a phase II clinical trial of immunization for recurrent UTI were statistically analysed for associations between HLA-A, -B, -DR, or -DQ phenotype and postimmunization infection course. Women who received the vaccine and had HLA-DR phenotypes other than DR2 had significantly delayed times to re-infection compared with women receiving placebo. Vaccine-treated patients with the HLA-DR2 phenotype had re-infection courses that were not different than women receiving placebo. These results indicate that the efficacy of a vaginal mucosal UTI vaccine may be influenced by an individual's HLA-DR phenotype.
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阴道粘膜免疫治疗复发性尿路感染：II 期临床试验。
DOI：
--
发表时间：
1997
期刊：
The Journal of urology.
影响因子：
--
作者：
Uehling,DT;Hopkins,WJ;Balish,E;Xing,Y;Heisey,DM
通讯作者：
Heisey,DM
耶尔森氏菌关节炎、免疫功能和组织相容性抗原。
DOI：
--
发表时间：
2009
期刊：
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology
影响因子：
--
作者：
H. Repo;M. Leirisalo;M. Gripenberg;S. Koskimies;S. Kontiainen;O. Laitinen
通讯作者：
O. Laitinen
类风湿性关节炎中分枝杆菌抗体水平的 HLA-DR 相关同种型特异性调节。
影响因子：
4.6
作者：
G. Bahr;G. Rook;A. Shahin;J. Stanford;M. Sattar;K. Behbehani
通讯作者：
K. Behbehani
影响因子：
158.5
作者：
RAZ, R;STAMM, WE
通讯作者：
STAMM, WE
人类 T 细胞识别甲型流感核蛋白。
影响因子：
4.4
作者：
S. Brett;J. Blau;C. Hughes;J. Rhodes;F. Liew;J. Tite
通讯作者：
J. Tite