Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.
Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.
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DOI：
10.1016/j.cell.2021.06.004
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发表时间：
2021-07-08
期刊：
影响因子：
64.5
通讯作者：
Casanova JL
中科院分区：
文献类型：
--
作者：
Béziat V;Rapaport F;Hu J;Titeux M;Bonnet des Claustres M;Bourgey M;Griffin H;Bandet É;Ma CS;Sherkat R;Rokni-Zadeh H;Louis DM;Changi-Ashtiani M;Delmonte OM;Fukushima T;Habib T;Guennoun A;Khan T;Bender N;Rahman M;About F;Yang R;Rao G;Rouzaud C;Li J;Shearer D;Balogh K;Al Ali F;Ata M;Dabiri S;Momenilandi M;Nammour J;Alyanakian MA;Leruez-Ville M;Guenat D;Materna M;Marcot L;Vladikine N;Soret C;Vahidnezhad H;Youssefian L;Saeidian AH;Uitto J;Catherinot É;Navabi SS;Zarhrate M;Woodley DT;Jeljeli M;Abraham T;Belkaya S;Lorenzo L;Rosain J;Bayat M;Lanternier F;Lortholary O;Zakavi F;Gros P;Orth G;Abel L;Prétet JL;Fraitag S;Jouanguy E;Davis MM;Tangye SG;Notarangelo LD;Marr N;Waterboer T;Langlais D;Doorbar J;Hovnanian A;Christensen N;Bossuyt X;Shahrooei M;Casanova JL
我们研究了一个人乳头瘤病毒（HPV）-2驱动的“树人”表型和两个异常严重的HPV 4驱动的疣的亲属。巨角形成一种HPV-2驱动的多灶性良性上皮肿瘤，在表皮基底层过度表达病毒癌基因。这些患者出乎意料地是一种特异性CD 28变异的纯合子。他们的T细胞上没有可检测到的CD 28，除了一小部分回复突变记忆CD 4 + T细胞。T细胞发育几乎不受影响，T细胞对CD 3和CD 2共刺激有反应，但对CD 28无反应。虽然患者在体外不显示HPV-2和HPV-4反应性CD 4 + T细胞，但它们在体内产生对这两种病毒特异性的抗体。CD 28缺陷型小鼠易受小鼠乳头瘤病毒MmuPV 1的皮肤感染。角质形成细胞中HPV-2和HPV-4的控制依赖于T细胞CD 28共活化途径。令人惊讶的是，人CD 28依赖性T细胞应答对于保护性免疫来说在很大程度上是多余的。通过研究一个由人乳头瘤病毒（HPV）感染引起的皮肤突起和严重疣的个体家族，Beziat等人发现，人CD 28在很大程度上是针对大多数感染的保护性免疫。遗传性CD 28缺陷仅轻微损害T细胞发育和功能，但角质形成细胞中HPV的控制依赖于T细胞CD 28共激活途径。
We study a patient with the human papilloma virus (HPV)-2-driven “tree-man” phenotype and two relatives with unusually severe HPV4-driven warts. The giant horns form an HPV-2-driven multifocal benign epithelial tumor overexpressing viral oncogenes in the epidermis basal layer. The patients are unexpectedly homozygous for a private CD28 variant. They have no detectable CD28 on their T cells, with the exception of a small contingent of revertant memory CD4+ T cells. T cell development is barely affected, and T cells respond to CD3 and CD2, but not CD28, costimulation. Although the patients do not display HPV-2- and HPV-4-reactive CD4+ T cells in vitro, they make antibodies specific for both viruses in vivo. CD28-deficient mice are susceptible to cutaneous infections with the mouse papillomavirus MmuPV1. The control of HPV-2 and HPV-4 in keratinocytes is dependent on the T cell CD28 co-activation pathway. Surprisingly, human CD28-dependent T cell responses are largely redundant for protective immunity. By studying a family of individuals with cutaneous protrusions and severe warts driven by human papilloma virus (HPV) infection, Beziat et al. discover that human CD28 is largely dispensable for protective immunity against most infections. Inherited CD28 deficiency only slightly impairs T cell development and function, but control of HPV in keratinocytes is dependent on the T cell CD28 co-activation pathway.
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DOI：
10.1093/bioinformatics/btu638
发表时间：
2015-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Anders S;Pyl PT;Huber W
通讯作者：
Huber W
影响因子：
46.9
作者：
Becht, Etienne;McInnes, Leland;Newell, Evan W.
通讯作者：
Newell, Evan W.
影响因子：
3.7
作者：
Antonsson, Annika;Green, Adele C.;Neale, Rachel E.
通讯作者：
Neale, Rachel E.
影响因子：
13.2
作者：
Cladel, Nancy M.;Jiang, Pengfei;Hu, Jiafen
通讯作者：
Hu, Jiafen
影响因子：
5.4
作者：
Black, Antony P. B.;Ardern-Jones, Michael R.;Ogg, Graham S.
通讯作者：
Ogg, Graham S.