Poly(vinylphosphonic acid-co-acrylic acid) hydrogels: The effect of copolymer composition on osteoblast adhesion and proliferation.
Poly(vinylphosphonic acid-co-acrylic acid) hydrogels: The effect of copolymer composition on osteoblast adhesion and proliferation.
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DOI：
10.1002/jbm.a.36234
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Budd PM
中科院分区：
文献类型：
--
作者：
Dey RE;Wimpenny I;Gough JE;Watts DC;Budd PM
临床上需要一种合成骨移植替代物，其可用于手术干预部位以促进骨再生。聚（乙烯基膦酸-共-丙烯酸）（PVPA-co-AA）最近已被确定为用于骨组织支架的潜在候选者。假设PVPA-co-AA可与骨矿物质表面的二价钙离子结合，以控制基质矿化并促进骨形成。在这项研究中，PVPA-co-AA的水凝胶已经产生，并研究了共聚物组成对凝胶的结构和性能的影响。发现VPA含量的增加导致产生具有高孔隙率和更大溶胀能力的水凝胶。因此，在这些水凝胶上观察到改善的细胞粘附和增殖，以及优良的上级细胞铺展形态。此外，尽管聚（丙烯酸）凝胶显示出相对易碎，但VPA含量的增加产生了更柔韧的水凝胶，其可以更容易地模制到骨缺损部位。因此，这项工作表明，PVPA-co-AA水凝胶的机械和细胞粘附性能可以通过改变共聚物组成来调整特定应用。© 2017 The Authors Journal of Biomedical Materials Research Part A由Wiley Periodicals，Inc.出版。J Biomed Mater Res Part A：106A：255-264，2018.
There is a clinical need for a synthetic bone graft substitute that can be used at sites of surgical intervention to promote bone regeneration. Poly(vinylphosphonic acid‐co‐acrylic acid) (PVPA‐co‐AA) has recently been identified as a potential candidate for use in bone tissue scaffolds. It is hypothesized that PVPA‐co‐AA can bind to divalent calcium ions on bone mineral surfaces to control matrix mineralization and promote bone formation. In this study, hydrogels of PVPA‐co‐AA have been produced and the effect of copolymer composition on the structure and properties of the gels was investigated. It was found that an increase in VPA content led to the production of hydrogels with high porosities and greater swelling capacities. Consequently, improved cell adhesion and proliferation was observed on these hydrogels, as well as superior cell spreading morphologies. Furthermore, whereas poly(acrylic acid) gels were shown to be relatively brittle, an increase in VPA content created more flexible hydrogels that can be more easily molded into bone defect sites. Therefore, this work demonstrates that the mechanical and cell adhesion properties of PVPA‐co‐AA hydrogels can be tuned for the specific application by altering the copolymer composition. © 2017 The Authors Journal of Biomedical Materials Research Part A Published by Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 255–264, 2018.
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