Home-site advantage for host species-specific gut microbiota.
Home-site advantage for host species-specific gut microbiota.
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DOI：
10.1126/sciadv.adf5499
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发表时间：
2023-05-12
期刊：
影响因子：
13.6
通讯作者：
Moeller, Andrew H.
中科院分区：
文献类型：
--
作者：
Sprockett, Daniel D.;Price, Jeffrey D.;Juritsch, Anthony F.;Schmaltz, Robert J.;Real, Madalena V. F.;Goldman, Samantha L.;Sheehan, Michael;Ramer-Tait, Amanda E.;Moeller, Andrew H.
哺乳动物拥有不同组成的肠道微生物群落，但维持共生体对宿主物种特异性的机制尚不清楚。在这里，我们证明了家鼠（家鼠）的自然选择驱动了家鼠肠道微生物群从本地和非本地微生物群的混合物中的确定性组装。在无菌野生型（WT）和Rag1敲除（Rag1−/−）家鼠中，来自野生家鼠和其他小鼠物种（小家鼠和Peromyscus spp.）的竞争微生物群显示出对本地肠道细菌的广泛适应性优势。在WT和Rag1 - / -小鼠中，本地细菌谱系明显优于非本地细菌谱系，表明本地微生物群具有独立于宿主适应性免疫的主场优势。然而，在WT宿主中被选择的少数原生细菌门和厚壁菌门在Rag1−/−宿主中不被偏爱或不被偏爱，这表明Rag1介导了这些菌株的适应性优势。这项研究证明了本地肠道细菌的家乡优势，与肠道微生物群对其哺乳动物物种的本地适应一致。本地细菌的适应性优势是家鼠肠道菌群组装的基础。
Mammalian species harbor compositionally distinct gut microbial communities, but the mechanisms that maintain specificity of symbionts to host species remain unclear. Here, we show that natural selection within house mice (Mus musculus domesticus) drives deterministic assembly of the house-mouse gut microbiota from mixtures of native and non-native microbiotas. Competing microbiotas from wild-derived lines of house mice and other mouse species (Mus and Peromyscus spp.) within germ-free wild-type (WT) and Rag1-knockout (Rag1−/−) house mice revealed widespread fitness advantages for native gut bacteria. Native bacterial lineages significantly outcompeted non-native lineages in both WT and Rag1−/− mice, indicating home-site advantage for native microbiota independent of host adaptive immunity. However, a minority of native Bacteriodetes and Firmicutes favored by selection in WT hosts were not favored or disfavored in Rag1−/− hosts, indicating that Rag1 mediates fitness advantages of these strains. This study demonstrates home-site advantage for native gut bacteria, consistent with local adaptation of gut microbiota to their mammalian species. Adaptive advantages for native bacteria underlie assembly of the house-mouse gut microbiota.
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影响因子：
9.8
作者：
Brooks AW;Kohl KD;Brucker RM;van Opstal EJ;Bordenstein SR
通讯作者：
Bordenstein SR
影响因子：
7.7
作者：
Martínez I;Maldonado-Gomez MX;Gomes-Neto JC;Kittana H;Ding H;Schmaltz R;Joglekar P;Cardona RJ;Marsteller NL;Kembel SW;Benson AK;Peterson DA;Ramer-Tait AE;Walter J
通讯作者：
Walter J
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
14.9
作者：
Letunic I;Bork P
通讯作者：
Bork P
影响因子：
28.3
作者：
Brito, Ilana L.;Gurry, Thomas;Alm, Eric J.
通讯作者：
Alm, Eric J.