Brain Entropy During Aging Through a Free Energy Principle Approach.
Brain Entropy During Aging Through a Free Energy Principle Approach.
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DOI：
10.3389/fnhum.2021.647513
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发表时间：
2021
影响因子：
2.9
通讯作者：
Cordes D
中科院分区：
文献类型：
--
作者：
Cieri F;Zhuang X;Caldwell JZK;Cordes D
近年来，神经复杂性和脑熵(BEN)受到了越来越多的关注。在各种值得注意的研究中，神经信号的动力学及其与信息处理的关系继续通过不同的方法进行研究。在意识减退的状态下，自发神经活动的频率会降低。这一证据已经在初级意识状态，如迷幻状态中得到了证明，被冠以“熵大脑假说”的名义。在这篇手稿中，我们建议将这一假设扩展到生理性和病理性衰老。我们回顾了大脑复杂性的这一特定方面，提到了研究本处于初级意识状态的研究，并将这一观点扩展到神经老化领域，重点是静息状态功能磁共振成像。我们首先介绍了关于熵和神经复杂性的历史和概念概念，根据自由能原理，将大脑视为一个复杂的非线性动态适应系统。然后，我们回顾了这一领域的研究，分析了神经认知系统的目的是从神经信号的动力学和功能连通性的角度来维持秩序和混沌之间的动态平衡的观点。在我们的探索中，我们将回顾关于急性迷幻状态和更多慢性精神状态和特征的研究，例如精神分裂症的研究，以显示这些状态下的熵增加。然后我们将我们的探索扩展到生理和病理衰老，其中Ben减少。最后，我们提出了对这些结果的解释，定义了初级状态本和认知老化的总体趋势。
Neural complexity and brain entropy (BEN) have gained greater interest in recent years. The dynamics of neural signals and their relations with information processing continue to be investigated through different measures in a variety of noteworthy studies. The BEN of spontaneous neural activity decreases during states of reduced consciousness. This evidence has been showed in primary consciousness states, such as psychedelic states, under the name of “the entropic brain hypothesis.” In this manuscript we propose an extension of this hypothesis to physiological and pathological aging. We review this particular facet of the complexity of the brain, mentioning studies that have investigated BEN in primary consciousness states, and extending this view to the field of neuroaging with a focus on resting-state functional Magnetic Resonance Imaging. We first introduce historic and conceptual ideas about entropy and neural complexity, treating the mindbrain as a complex nonlinear dynamic adaptive system, in light of the free energy principle. Then, we review the studies in this field, analyzing the idea that the aim of the neurocognitive system is to maintain a dynamic state of balance between order and chaos, both in terms of dynamics of neural signals and functional connectivity. In our exploration we will review studies both on acute psychedelic states and more chronic psychotic states and traits, such as those in schizophrenia, in order to show the increase of entropy in those states. Then we extend our exploration to physiological and pathological aging, where BEN is reduced. Finally, we propose an interpretation of these results, defining a general trend of BEN in primary states and cognitive aging.
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影响因子：
4.3
作者：
Bressler SL;Kelso JA
通讯作者：
Kelso JA
影响因子：
1.5
作者：
Beni MD
通讯作者：
Beni MD
影响因子：
2.5
作者：
Azevedo, Frederico A. C.;Carvalho, Ludmila R. B.;Herculano-Houzel, Suzana
通讯作者：
Herculano-Houzel, Suzana
影响因子：
5.2
作者：
Andrews-Hanna JR;Smallwood J;Spreng RN
通讯作者：
Spreng RN
DOI：
10.1016/j.nicl.2018.02.035
发表时间：
2018
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Bordier C;Nicolini C;Forcellini G;Bifone A
通讯作者：
Bifone A