Influence of early stress on social abilities and serotonergic functions across generations in mice.
Influence of early stress on social abilities and serotonergic functions across generations in mice.
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DOI：
10.1371/journal.pone.0021842
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Mansuy IM
中科院分区：
文献类型：
--
作者：
Franklin TB;Linder N;Russig H;Thöny B;Mansuy IM
在发育早期暴露在不利环境中是几种精神疾病的已知危险因素，包括反社会行为和人格障碍。在这里，我们在成年小鼠中使用不可预测的母体分离和出生后早期的母体压力来诱导社交焦虑和改变社会识别记忆。我们发现，这些社会缺陷不仅在直接承受压力的动物身上明显存在，而且还会在两代人之间传递给后代。这些缺陷与5-羟色胺能信号受损有关，尤其是中缝背核5HT1a受体表达减少，中缝背投射区5-羟色胺水平升高。这些发现强调了社会行为和5-羟色胺能通路对早期应激的易感性，以及它们的扰动在几代人之间的持久性。
Exposure to adverse environments during early development is a known risk factor for several psychiatric conditions including antisocial behavior and personality disorders. Here, we induced social anxiety and altered social recognition memory in adult mice using unpredictable maternal separation and maternal stress during early postnatal life. We show that these social defects are not only pronounced in the animals directly subjected to stress, but are also transmitted to their offspring across two generations. The defects are associated with impaired serotonergic signaling, in particular, reduced 5HT1A receptor expression in the dorsal raphe nucleus, and increased serotonin level in a dorsal raphe projection area. These findings underscore the susceptibility of social behaviors and serotonergic pathways to early stress, and the persistence of their perturbation across generations.
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