Transcriptional expressions of Chromobox 1/2/3/6/8 as independent indicators for survivals in hepatocellular carcinoma patients.
Transcriptional expressions of Chromobox 1/2/3/6/8 as independent indicators for survivals in hepatocellular carcinoma patients.
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Chromobox 1/2/3/6/8的转录表达作为肝细胞癌患者生存的独立指标
DOI：
10.18632/aging.101658
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发表时间：
2018-11-27
期刊：
影响因子：
--
通讯作者：
Peng L
中科院分区：
文献类型：
--
作者：
Ning G;Huang YL;Zhen LM;Xu WX;Jiao Q;Yang FJ;Wu LN;Zheng YY;Song J;Wang YS;Xie C;Peng L
染色体盒（CBX）蛋白是表观遗传调控复合物的重要组成部分，已知在肝细胞癌（HCC）中起关键作用。关于不同CBX在HCC中的功能知之甚少。为了解决这个问题，该研究使用ONCOMINE、UALCAN、人类蛋白质图谱、Kaplan-Meier绘图仪、c-BioPortal数据库研究了CBX在HCC预后中的作用。8个CBXs成员的过表达与HCC患者的临床分期和病理分级显著相关。此外，CBX 1/2/3/6/8的高表达与肝癌患者的总生存期（OS）缩短显著相关，而CBX 7的高表达与肝癌患者的OS良好相关。多因素分析还显示，CBX 1/2/3/6/8的高表达是肝癌患者OS缩短的独立预后因素。此外，在HCC患者中也观察到高CBX突变率（51%），并且CBX的遗传改变与HCC患者的OS和无病生存期（DFS）较短相关。综上所述，这些结果表明CBX 1/2/3/6/8可以作为HCC患者生存的预后生物标志物。
Chromobox (CBX) proteins are important components of epigenetic regulation complexes known to play key roles in hepatocellular carcinoma (HCC). Little is known about the function of distinct CBXs in HCC. To address this issue, the study investigated the roles of CBXs in the prognosis of HCC using ONCOMINE, UALCAN, Human Protein Atlas, Kaplan-Meier Plotter, c-BioPortal databases. Over expressions of 8 CBXs members were found to be significantly associated with clinical cancer stages and pathological tumor grades in HCC patients. Besides, higher mRNA expressions of CBX1/2/3/6/8 were found to be significantly associated with shorter overall survival (OS) in HCC patients, while higher mRNA expression of CBX7 was associated with favorable OS. Multivariate analysis also showed that high mRNA expressions of CBX1/2/3/6/8 were independent prognostic factors for shorter OS of HCC patients. Moreover, high mutation rate of CBXs (51%) was also observed in HCC patients, and genetic alteration in CBXs was associated with shorter OS and disease-free survival (DFS) in HCC patients. Taken together, these results indicated that CBX1/2/3/6/8 could be prognostic biomarkers for survivals of HCC patients.
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影响因子：
8.8
作者：
Clermont, P-L;Sun, L.;Crea, F.;Thu, K. L.;Zhang, A.;Parolia, A.;Lam, W. L.;Helgason, C. D.
通讯作者：
Helgason, C. D.
影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
影响因子：
4.3
作者：
Ma, Li;Chua, Mei-Sze;So, Samuel
通讯作者：
So, Samuel
影响因子：
--
作者：
Hinz, S.;Kempkensteffen, C.;Weikert, S.
通讯作者：
Weikert, S.
影响因子：
3.7
作者：
Lee YH;Liu X;Qiu F;O'Connor TR;Yen Y;Ann DK
通讯作者：
Ann DK