Lactic dehydrogenase virus infection enhances parasite egg production and inhibits eosinophil and mast cell responses in mice infected with the nematode Nippostrongylus brasiliensis
Lactic dehydrogenase virus infection enhances parasite egg production and inhibits eosinophil and mast cell responses in mice infected with the nematode Nippostrongylus brasiliensis
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乳酸脱氢酶病毒感染可增强感染巴西圆线虫的小鼠体内寄生虫卵的产生并抑制嗜酸性粒细胞和肥大细胞反应
作者：
Morimoto;Yamada;Arizono;Hayashi
本文研究了乳酸脱氢酶病毒（LDV）感染对巴西日本圆线虫保护性免疫应答的影响。慢性LDV感染小鼠在N.巴西人感染并发LDV感染也抑制外周血嗜酸性粒细胞增多症和肺肥大细胞增多症引起的这种线虫。LDV感染小鼠淋巴结中IFN-γ mRNA的表达水平高于对照小鼠。巴西人感染此外，在N.巴西人感染这些结果表明，LDV感染调节针对N.通过激活辅助性T细胞1型巴西感染。
The effects of lactic dehydrogenase virus (LDV) infection on the protective immune responses to the nematode Nippostrongylus brasiliensis were studied. Mice with chronic LDV infection showed significantly higher levels of parasite egg production than non‐LDV‐infected (control) mice after N. brasiliensis infection. Concurrent LDV infection also suppressed peripheral blood eosinophilia and the lung mastocytosis induced by this nematode. LDV infection showed higher expression levels of the interferon‐γ (IFN‐γ) mRNA in lymph nodes compared with control mice before N. brasiliensis infection. In addition, the IgG2a production in LDV‐infected mice was higher than that in control mice before and after N. brasiliensis infection. These results suggest that LDV infection modulates protective immune responses against N. brasiliensis infection by the activation of T‐helper type 1 cells.
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DOI：
10.1073/pnas.88.13.5513
发表时间：
1991-07-01
影响因子：
11.1
作者：
URBAN, JF;KATONA, IM;FINKELMAN, FD
通讯作者：
FINKELMAN, FD
影响因子：
4.4
作者：
T. Gajewski;F. Fitch
通讯作者：
T. Gajewski;F. Fitch
小鼠和中国仓鼠的次黄嘌呤鸟嘌呤磷酸核糖基转移酶基因：cDNA重组体的构建和序列分析。
影响因子：
14.9
作者：
Konecki,DS;Brennand,J;Fuscoe,JC;Caskey,CT;Chinault,AC
通讯作者：
Chinault,AC
影响因子：
4.4
作者：
Joseph F Urban;C. Maliszewski;K. Madden;I. Katona;F. Finkelman
通讯作者：
Joseph F Urban;C. Maliszewski;K. Madden;I. Katona;F. Finkelman
在遗传性肥大细胞缺陷的 WBB6F1-W/Wv 小鼠中，特发性慢性皮炎部位出现大量肥大细胞。
影响因子：
20.3
作者：
Galli,SJ;Arizono,N;Murakami,T;Dvorak,AM;Fox,JG
通讯作者：
Fox,JG