Cognitive and Emotional Disturbances Due to COVID-19: An Exploratory Study in the Rehabilitation Setting.
Cognitive and Emotional Disturbances Due to COVID-19: An Exploratory Study in the Rehabilitation Setting.
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DOI：
10.3389/fneur.2021.643646
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发表时间：
2021
影响因子：
3.4
通讯作者：
Alemanno F
中科院分区：
文献类型：
--
作者：
Pistarini C;Fiabane E;Houdayer E;Vassallo C;Manera MR;Alemanno F
冠状病毒病19（COVID-19）可导致神经、精神、心理和社会心理障碍。关于COVID-19认知影响的文献仍然有限。本研究的目的是评估需要功能康复的COVID-19和COVID-19后患者的认知缺陷和情绪困扰。具体而言，本研究探讨并比较了疾病亚急性期（COVID-19组）和产后期（后COVID-19组）患者的认知和心理状态。40名入住康复单位的患者入组研究，并根据疾病阶段分为两组：（a）COVID-19组（n = 20）和（B）COVID-19后组（n = 20）。所有患者均接受神经心理学评估，包括简易精神状态评估（MMSE）、蒙特利尔认知评估（莫卡）、汉密尔顿抑郁量表和事件影响量表修订版（IES-R）。与新冠肺炎后组（5%）相比，新冠肺炎组（35%）的大部分患者在总MMSE中表现出神经心理学缺陷，而两组中的大多数（75-70%）均报告了总莫卡中的认知障碍。与COVID组相比，COVID后组在MMSE语言子测试（p = 0.02）和莫卡执行功能（p = 0.05），语言（p = 0.01）和抽象（p = 0.02）子测试中的得分显著更高。关于情绪障碍，约40%的患者表现出轻度至中度抑郁（57.9-60%）。与COVID组相比，COVID-19后组在IES-R上报告的痛苦水平显著更高（p = 0.02）。这些发现强调了COVID-19感染可能引起的神经心理和心理症状的严重性，以及需要量身定制的康复，包括认知训练和心理支持。
The coronavirus disease 19 (COVID-19) can cause neurological, psychiatric, psychological, and psychosocial impairments. Literature regarding cognitive impact of COVID-19 is still limited. The aim of this study was to evaluate cognitive deficits and emotional distress among COVID-19 and post–COVID-19 patients who required functional rehabilitation. Specifically, this study explored and compared cognitive and psychological status of patients in the subacute phase of the disease (COVID-19 group) and patients in the postillness period (post–COVID-19 group). Forty patients admitted to rehabilitation units were enrolled in the study and divided into two groups according to the phase of the disease: (a) COVID-19 group (n = 20) and (b) post–COVID-19 group (n = 20). All patients underwent a neuropsychological assessment including Mini-Mental State Evaluation (MMSE), Montreal Cognitive Assessment (MoCA), Hamilton Rating Scale for Depression, and Impact of Event Scale–Revised (IES-R). A larger part of the COVID group showed neuropsychological deficits in the total MMSE (35%) compared to the post-COVID group (5%), whereas the majority of both groups (75–70%) reported cognitive impairments in the total MoCA. The post-COVID group reported significantly higher score in MMSE subtests of language (p = 0.02) and in MoCA subtests of executive functions (p = 0.05), language (p = 0.01), and abstraction (p = 0.02) compared to the COVID group. Regarding emotional disturbances, ~40% of patients presented with mild to moderate depression (57.9–60%). The post–COVID-19 group reported significantly higher levels of distress at the IES-R compared to the COVID group (p = 0.02). These findings highlight the gravity of neuropsychological and psychological symptoms that can be induced by COVID-19 infection and the need for tailored rehabilitation, including cognitive training and psychological support.
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影响因子：
7.8
作者：
Sheng, B;Cheng, SKW;Chan, ELY
通讯作者：
Chan, ELY
多器官感染和SAR的发病机理。
影响因子：
15.3
作者：
Gu, Jiang;Gong, Encong;Zhang, Bo;Zheng, Jie;Gao, Zifen;Zhong, Yanfeng;Zou, Wanzhong;Zhan, Jun;Wang, Shenglan;Xie, Zhigang;Zhuang, Hui;Wu, Bingquan;Zhong, Haohao;Shao, Hongquan;Fang, Weigang;Gao, Dongshia;Pei, Fei;Li, Xingwang;He, Zhongpin;Xu, Danzhen;Shi, Xeying;Anderson, Virginia M;Leong, Anthony S-Y
通讯作者：
Leong, Anthony S-Y
影响因子：
2.3
作者：
Gorini A;Fiabane E;Sommaruga M;Barbieri S;Sottotetti F;La Rovere MT;Tremoli E;Gabanelli P
通讯作者：
Gabanelli P
影响因子：
4.4
作者：
Dong, YanHong;Sharma, Vijay Kumar;Chen, Christopher
通讯作者：
Chen, Christopher
DOI：
10.1016/j.apmr.2020.05.015
发表时间：
2020-09-01
影响因子：
4.3
作者：
Iannaccone, Sandro;Castellazzi, Paola;Scarpellini, Paolo
通讯作者：
Scarpellini, Paolo