Global spread of Carbapenemase-producing Enterobacteriaceae.

Global spread of Carbapenemase-producing Enterobacteriaceae.
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DOI:
10.3201/eid1710.110655
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发表时间:
2011-10
影响因子:
11.8
通讯作者:
Poirel L
Poirel L
中科院分区:
医学2区
文献类型:
--
作者:
Nordmann P;Naas T;Poirel L

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这些耐药性特征已在医院和社区获得性感染中被确定。在过去的10年里,肠杆菌科中碳青霉烯酶的报道越来越多。肺炎克雷伯菌碳青霉烯酶在美国和世界范围内均有报告,至少在美国和希腊具有明显的地方性。金属酶(维罗纳整合子编码的金属-β-内酰胺酶,IMP)也在全球范围内报告,南欧和亚洲的患病率较高。苯唑西林酶-48型碳青霉烯酶主要在地中海和欧洲国家以及印度被鉴定。最近发现的新德里金属-β-内酰胺酶-1生产者令人担忧,这些生产者最初在英国、印度和巴基斯坦,现在遍布全球。检测碳青霉烯酶产生者感染的患者和携带者对于预防其传播是必要的。碳青霉烯酶基因的鉴定主要依赖于分子技术,而携带者的检测可以通过使用筛选培养基进行。这一策略可能有助于预防由碳青霉烯酶生产者,特别是克雷伯菌引起的医院暴发。肺炎。
These resistance traits have been identified among nosocomial and community-acquired infections. Carbapenemases increasingly have been reported in Enterobacteriaceae in the past 10 years. Klebsiella pneumoniae carbapenemases have been reported in the United States and then worldwide, with a marked endemicity at least in the United States and Greece. Metallo-enzymes (Verona integron–encoded metallo-β-lactamase, IMP) also have been reported worldwide, with a higher prevalence in southern Europe and Asia. Carbapenemases of the oxacillinase-48 type have been identified mostly in Mediterranean and European countries and in India. Recent identification of New Delhi metallo-β-lactamase-1 producers, originally in the United Kingdom, India, and Pakistan and now worldwide, is worrisome. Detection of infected patients and carriers with carbapenemase producers is necessary for prevention of their spread. Identification of the carbapenemase genes relies mostly on molecular techniques, whereas detection of carriers is possible by using screening culture media. This strategy may help prevent development of nosocomial outbreaks caused by carbapenemase producers, particularly K. pneumoniae.
DOI: 10.3201/eid1609.091389
发表时间: 2010-09
影响因子: 11.8
作者:
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影响因子: 4.9
作者:
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DOI: 10.1093/jac/dkq520
发表时间: 2011-04-01
影响因子: 5.2
作者:
Nordmann, Patrice;Poirel, Laurent;Walsh, Timothy R.
通讯作者: Walsh, Timothy R.