Temporal dynamics of European bat Lyssavirus type 1 and survival of Myotis myotis bats in natural colonies.
Temporal dynamics of European bat Lyssavirus type 1 and survival of Myotis myotis bats in natural colonies.
复制标题
欧洲蝙蝠狂犬病病毒 1 型的时间动态和鼠耳蝠在自然群体中的存活。
DOI：
10.1371/journal.pone.0000566
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发表时间：
2007-06-27
期刊：
影响因子：
3.7
通讯作者：
Serra-Cobo, Jordi
中科院分区：
文献类型：
--
作者：
Amengual, Blanca;Bourhy, Herve;Lopez-Roig, Marc;Serra-Cobo, Jordi
最近在蝙蝠中发现了许多新出现的引起公共卫生关注的RNA病毒。然而，这些病毒在自然蝙蝠群落中的动态目前尚不清楚。因此，由于缺乏信息，无法预测这些病毒的传播情况，也无法制定适当的控制措施。为了这个目的，我们收集了流行病学，病毒学和生态学数据在两个殖民地的食虫蝙蝠（鼠耳蝠）位于西班牙和感染的最常见的蝙蝠狂犬病毒在欧洲发现，欧洲蝙蝠狂犬病毒亚型1（EBLV-1）的12年的纵向研究。这项积极的调查表明，周期性狂犬病病毒感染发生在易感，免疫和感染蝙蝠的数量周期性振荡。在一些个体中检测到免疫持续一年以上。这些数据进一步用于饲料模型，以分析EBLV-1的时间动态和蝙蝠的存活率。根据这些模型，感染的特点是预测低的基本繁殖率（R 0 = 1.706）和短的传染期（D = 5.1天）。 与大多数感染狂犬病的非飞行动物的观察结果相反，存活模型显示在EBLV-1感染M.鼠耳蝠这些发现在记录狂犬病毒阳性蝙蝠的殖民地管理方面具有相当大的公共卫生意义，并证实了狂犬病传播给人类的潜在风险。对蝙蝠群体中狂犬病病毒动态的更深入了解也为研究蝙蝠如何促进其他公共卫生病毒的维持和传播提供了一个模型。
Many emerging RNA viruses of public health concern have recently been detected in bats. However, the dynamics of these viruses in natural bat colonies is presently unknown. Consequently, prediction of the spread of these viruses and the establishment of appropriate control measures are hindered by a lack of information. To this aim, we collected epidemiological, virological and ecological data during a twelve-year longitudinal study in two colonies of insectivorous bats (Myotis myotis) located in Spain and infected by the most common bat lyssavirus found in Europe, the European bat lyssavirus subtype 1 (EBLV-1). This active survey demonstrates that cyclic lyssavirus infections occurred with periodic oscillations in the number of susceptible, immune and infected bats. Persistence of immunity for more than one year was detected in some individuals. These data were further used to feed models to analyze the temporal dynamics of EBLV-1 and the survival rate of bats. According to these models, the infection is characterized by a predicted low basic reproductive rate (R0 = 1.706) and a short infectious period (D = 5.1 days). In contrast to observations in most non-flying animals infected with rabies, the survival model shows no variation in mortality after EBLV-1 infection of M. myotis. These findings have considerable public health implications in terms of management of colonies where lyssavirus-positive bats have been recorded and confirm the potential risk of rabies transmission to humans. A greater understanding of the dynamics of lyssavirus in bat colonies also provides a model to study how bats contribute to the maintenance and transmission of other viruses of public health concern.
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影响因子：
4.1
作者：
Bickham, JW;Patton, JC;Honeycutt, RL
通讯作者：
Honeycutt, RL
DOI：
10.2807/esm.10.11.00575-en
发表时间：
2005-11-01
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Bourhy, H;Dacheux, L;Mailles, A
通讯作者：
Mailles, A
影响因子：
5.4
作者：
Davis, PL;Holmes, EC;Bourhy, H
通讯作者：
Bourhy, H
影响因子：
11.8
作者：
Reynes JM;Molia S;Audry L;Hout S;Ngin S;Walston J;Bourhy H
通讯作者：
Bourhy H
影响因子：
11.8
作者：
Brookes SM;Aegerter JN;Smith GC;Healy DM;Jolliffe TA;Swift SM;Mackie IJ;Pritchard JS;Racey PA;Moore NP;Fooks AR
通讯作者：
Fooks AR