Mouse models for infectious diseases caused by Staphylococcus aureus.
Mouse models for infectious diseases caused by Staphylococcus aureus.
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DOI：
10.1016/j.jim.2014.04.007
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发表时间：
2014-08
影响因子：
2.2
通讯作者：
Schneewind O
中科院分区：
文献类型：
--
作者：
Kim HK;Missiakas D;Schneewind O
金黄色葡萄球菌-人类皮肤、鼻孔和胃肠道的寄生虫-也是细菌性皮肤和软组织感染（SSTI）、菌血症、败血症、腹膜炎、肺炎和心内膜炎的主要原因。耐甲氧西林金黄色葡萄球菌（MRSA）是耐药菌株。金黄色葡萄球菌）是常见的，并且代表了治疗挑战。目前的研究和开发工作试图通过疫苗和免疫治疗来应对MRSA感染的挑战。小鼠已被用作S.金黄色葡萄球菌SSTI、菌血症、败血症、腹膜炎和心内膜炎。这项工作导致了关键毒力因子，候选疫苗抗原或免疫治疗剂的鉴定，这些仍然需要人体临床试验来确定疗效。过去人类临床试验的失败引起了人们对小鼠是否是S。金黄色葡萄球菌病S.金黄色葡萄球菌引起慢性持续性感染，即使使用抗生素或手术干预，也会在人类和小鼠中复发。S的行列式已经鉴定了金黄色葡萄球菌逃避人类先天性和适应性免疫应答，然而这些中只有一些在小鼠中相关。未来的研究必须整合这些见解，并完善特定S的实验小鼠模型。金黄色葡萄球菌疾病，以准确预测候选疫苗和免疫治疗剂的失败或成功。
Staphylococcus aureus - a commensal of the human skin, nares and gastrointestinal tract - is also a leading cause of bacterial skin and soft tissue infection (SSTIs), bacteremia, sepsis, peritonitis, pneumonia and endocarditis. Antibiotic-resistant strains, designaed MRSA (methicillin-resistant S. aureus), are common and represent a therapeutic challenge. Current research and development efforts seek to address the challenge of MRSA infections through vaccines and immune therapeutics. Mice have been used as experimental models for S. aureus SSTI, bacteremia, sepsis, peritonitis and endocarditis. This work led to the identification of key virulence factors, candidate vaccine antigens or immune-therapeutics that still require human clinical testing to establish efficacy. Past failures of human clinical trials raised skepticism whether the mouse is an appropriate model for S. aureus disease in humans. S. aureus causes chronic-persistent infections that, even with antibiotic or surgical intervention, reoccur in humans and in mice. Determinants of S. aureus evasion from human innate and adaptive immune responses have been identified, however only some of these are relevant in mice. Future research must integrate these insights and refine the experimental mouse models for specific S. aureus diseases to accurately predict the failure or success for candidate vaccines and immune-therapeutics.
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4.2
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