The orexin receptor 1 (OX1R) in the rostral medullary raphe contributes to the hypercapnic chemoreflex in wakefulness, during the active period of the diurnal cycle.
The orexin receptor 1 (OX1R) in the rostral medullary raphe contributes to the hypercapnic chemoreflex in wakefulness, during the active period of the diurnal cycle.
复制标题
在昼夜周期的活跃期，延髓中缝头端的食欲素受体 1 (OX1R) 有助于清醒时的高碳酸化学反射。
DOI：
10.1016/j.resp.2009.12.002
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发表时间：
2010-01-31
影响因子：
2.3
通讯作者：
Nattie, Eugene
中科院分区：
文献类型：
--
作者：
Dias, Mirela Barros;Li, Aihua;Nattie, Eugene
已有研究表明，食欲素在觉醒时的高碳酸化反应中起重要作用，而梯形后核(RTN)中的OX1Rs参与了这一机制。我们推测，中缝吻端的OX1R也参与了高碳酸化反应。本文用SB-334867微透析法，在清醒和非快速眼动睡眠状态下，研究了7%CO_2中氧合酶1R的局部拮抗作用对清醒和非快速眼动睡眠大鼠在黑暗和光照条件下空气和7%CO_2中通气量的影响。在夜间清醒时，SB-334867可使7%CO2引起的过度通风减少16%，而在光照期则不明显。对睡眠没有显著影响。基础通气量、体温和V-̇O2无明显变化。在另一组微透析探头错位(中缝周围)的动物中没有观察到任何效果。我们的结论是，在大鼠的清醒状态下，延髓中缝吻端的OX1R参与了清醒状态下的高碳酸化反应。
It has been shown that orexin plays an important role in the hypercapnic chemoreflex during wakefulness, and OX1Rs in the retrotrapezoid nucleus (RTN) participate in this mechanism. We hypothesized that OX1R in the rostral medullary raphe (MR) also contributes to the hypercapnic chemoreflex. We studied the effects on ventilation in air and in 7% CO2 of focal antagonism of OX1R in the rostral MR by microdialysis of SB-334867 in rats during wakefulness and NREM sleep, under dark and light periods. During wakefulness in the dark period, but not in the light period, SB-334867 caused a 16% reduction of the hyperventilation induced by 7% CO2 compared with vehicle. There was no significant effect in sleep. The basal ventilation, body temperature and V̇O2 were not affected. No effect was observed in a separate group of animals which had the microdialysis probe misplaced (peri-raphe). We conclude that OX1R in the the rostral medullary raphe contribute to the hypercapnic chemoreflex in wakefulness, during the dark period in rats.
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