Prefrontal cortical activation associated with prospective memory while walking around a real-world street environment.
Prefrontal cortical activation associated with prospective memory while walking around a real-world street environment.
复制标题
DOI：
10.1016/j.neuroimage.2022.119392
复制
发表时间：
2022-09
期刊：
影响因子：
5.7
通讯作者：
Hamilton, Antonia
中科院分区：
文献类型：
--
作者：
Burgess, Paul W.;Crum, James;Pinti, Paola;Aichelburg, Clarisse;Oliver, Dominic;Lind, Frida;Power, Sarah;Swingler, Elizabeth;Hakim, Uzair;Merla, Arcangelo;Gilbert, Sam;Tachtsidis, Ilias;Hamilton, Antonia
关键词：
在英国伦敦散步时的神经成像。当保持未来的社会意图时，前额叶皮层会更活跃。大脑优先的分析方法提供了额外的解释力。前额叶皮层的功能性神经事件发生在街道的不同位置。.在前瞻记忆（PM）任务中，头侧PFC（10区）激活是常见的。但目前尚不清楚这些激活所指的是什么心理过程。认知神经科学理论的三个候选解释是：（i）对环境的监测;（ii）自发的意图提取;（iii）两者的结合。这些解释作出不同的预测的时间和空间模式的激活，将看到在喙PFC的自然设置。因此，我们使用便携式fNIRS绘制PFC中的功能事件，同时人们在实验室外执行PM任务，并在遇到提示时做出反应，以在这些解释之间做出决定。19个人被要求在英国伦敦的一条街道上行走。并执行各种任务，同时还记得在检测到前瞻记忆（PM）线索时做出反应。前瞻性记忆线索在本质上可以是社交性的（包括问候一个人），也可以是非社交性的（与停车计时器互动）。还有一些对比条件使我们能够确定与任务的前瞻记忆成分具体相关的激活。我们发现，保持社会和非社会意图与内侧和右半球吻侧前额叶皮层（BA 10）的广泛激活有关，这与之前许多基于实验室的前瞻性记忆功能磁共振成像研究一致。此外，当人们保持社交意图时，与非社交意图相比，外侧前额叶皮层（BA 45和46）的激活增加。然后，这些数据进行基于GLM的方法，用于自动识别功能事件（AIDE），并在激活事件发生时将参与者的位置定位在物理空间的地图上。结果表明，这些事件的空间和时间分布不是随机的，而是聚集在参与者似乎检索他们未来意图的区域周围（即，他们在哪里看到有意的暗示），以及他们在哪里执行这些暗示。与其他区域和任务相比，在PM条件下，BA 10中检测到的功能事件最频繁。移动的fNIRS可用于测量自由走动个体在实验室外的“真实的世界”情况下的前额叶皮层的高级认知功能。在数据中加入“大脑优先”的方法，使实验者不仅可以确定血液动力学变化何时发生，还可以确定血液动力学变化发生时参与者的位置。当试图将大脑和认知联系起来时，这可能非常有价值。
Neuroimaging of people while walking around London, England. Greater activation in prefrontal cortex when maintaining social future intentions. A brain-first analysis approach provided additional explanatory power. Functional neural events in prefrontal cortex occurred at different locations on the street. . Rostral PFC (area 10) activation is common during prospective memory (PM) tasks. But it is not clear what mental processes these activations index. Three candidate explanations from cognitive neuroscience theory are: (i) monitoring of the environment; (ii) spontaneous intention retrieval; (iii) a combination of the two. These explanations make different predictions about the temporal and spatial patterns of activation that would be seen in rostral PFC in naturalistic settings. Accordingly, we plotted functional events in PFC using portable fNIRS while people were carrying out a PM task outside the lab and responding to cues when they were encountered, to decide between these explanations. Nineteen people were asked to walk around a street in London, U.K. and perform various tasks while also remembering to respond to prospective memory (PM) cues when they detected them. The prospective memory cues could be either social (involving greeting a person) or non-social (interacting with a parking meter) in nature. There were also a number of contrast conditions which allowed us to determine activation specifically related to the prospective memory components of the tasks. We found that maintaining both social and non-social intentions was associated with widespread activation within medial and right hemisphere rostral prefrontal cortex (BA 10), in agreement with numerous previous lab-based fMRI studies of prospective memory. In addition, increased activation was found within lateral prefrontal cortex (BA 45 and 46) when people were maintaining a social intention compared to a non-social one. The data were then subjected to a GLM-based method for automatic identification of functional events (AIDE), and the position of the participants at the time of the activation events were located on a map of the physical space. The results showed that the spatial and temporal distribution of these events was not random, but aggregated around areas in which the participants appeared to retrieve their future intentions (i.e., where they saw intentional cues), as well as where they executed them. Functional events were detected most frequently in BA 10 during the PM conditions compared to other regions and tasks. Mobile fNIRS can be used to measure higher cognitive functions of the prefrontal cortex in “real world” situations outside the laboratory in freely ambulant individuals. The addition of a “brain-first” approach to the data permits the experimenter to determine not only when haemodynamic changes occur, but also where the participant was when it happened. This can be extremely valuable when trying to link brain and cognition.
登录
查看更多内容
影响因子：
2.6
作者：
Burgess, Paul W.;Gonen-Yaacovi, Gil;Volle, Emmanuelle
通讯作者：
Volle, Emmanuelle
影响因子：
2.3
作者：
Burgess, PW
通讯作者：
Burgess, PW
影响因子：
2.6
作者：
Burgess, PW;Scott, SK;Frith, CD
通讯作者：
Frith, CD
影响因子：
1.7
作者：
Dong, Dong;Wong, Lawrence K. F.;Luo, Zhiwei
通讯作者：
Luo, Zhiwei
影响因子：
2.6
作者：
Barban, Francesco;Carlesimo, Giovanni Augusto;Costa, Alberto
通讯作者：
Costa, Alberto