Identification of a heritable model of testicular germ cell tumor in the zebrafish.
Identification of a heritable model of testicular germ cell tumor in the zebrafish.
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DOI：
10.1089/zeb.2009.0613
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发表时间：
2009-12
期刊：
影响因子：
2
通讯作者：
Amatruda JF
中科院分区：
文献类型：
--
作者：
Neumann JC;Dovey JS;Chandler GL;Carbajal L;Amatruda JF
Germ cell tumors (GCTs) affect infants, children and adults and are the most common cancer type in young men. Progress in understanding the molecular basis of germ cell tumors has been hampered by a lack of suitable animal models. Here we report the identification of a zebrafish model of highly penetrant, heritable testicular germ cell tumor isolated as part of a forward-genetic screen for cancer-susceptibility genes. The mutant line develops spontaneous testicular tumors at a median age of 7 months, and pedigree analysis indicates dominant inheritance of the germ cell tumor susceptibility trait. The zebrafish model exhibits disruption of testicular tissue architecture and the accumulation of primitive, spermatogonial-like cells with loss of spermatocytic differentiation. Radiation treatment leads to apoptosis of the tumor cells and tumor regression. The germ cell tumor-susceptible line can serve as a model for understanding the mechanisms regulating germ cells in normal development and disease, and as a platform investigating new therapeutic approaches for germ cell tumors.
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