Neurophysiological correlates of cognitive control and approach motivation abnormalities in adolescent bipolar disorders.
Neurophysiological correlates of cognitive control and approach motivation abnormalities in adolescent bipolar disorders.
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DOI：
10.3758/s13415-019-00719-x
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发表时间：
2019-06
期刊：
影响因子：
--
通讯作者：
Urošević S
中科院分区：
文献类型：
--
作者：
Maresh EL;Stim JJ;Van Voorhis AC;Kang SS;Luciana M;Sponheim SR;Urošević S
对奖励相关刺激的超敏反应被认为是双相情感障碍（BD）的核心病因。然而，很少有人知道的作用，认知控制失调的奖励背景下，在BD，特别是在青春期。使用脑电图（EEG），我们探讨了99名青少年（n=53）和（n=46）BD在奖励努力（目标预期）和奖励实现（反馈）阶段的金钱激励延迟（MID）任务的认知控制过程和方法动机的变化。时间-频率分析得出额叶θ和额叶α不对称的认知控制和方法的动机，分别作为指标。多层次混合模型研究组的差异，以及年龄，性别和其他影响，额叶θ和额叶α不对称性在这两个阶段的任务和性能的准确性和反应时间。健康的青春期女孩表现出较低的额叶theta比青春期女孩与BD和青春期男孩与BD和没有奖励的预期和反馈。在各组中，青春期男孩在奖励预期和反馈过程中表现出比青春期女孩更大的相对左额叶α活动。在行为上，BD青少年表现出更快的反应，积极和消极的动机试验与中立的试验，而健康的青少年只有积极的动机试验更快的反应，BD青少年不太准确，在响应中立的试验相比，健康对照。这些研究结果揭示了规范和BD具体参与的方法动机和认知控制在不同阶段的奖励处理在青春期，并进一步提供证据，青少年性别差异在这些过程中。
Hypersensitivity to reward-relevant stimuli is theorized to be a core etiological factor in bipolar disorders (BD). However, little is known about the role of cognitive control dysregulation within reward contexts in BD, particularly during adolescence. Using electroencephalography (EEG), we explored alterations in cognitive control processes and approach motivation in 99 adolescents with (n=53) and without (n=46) BD during reward striving (target anticipation) and reward attainment (feedback) phases of a monetary incentive delay (MID) task. Time-frequency analysis yielded frontal theta and frontal alpha asymmetry as indices of cognitive control and approach motivation, respectively. Multilevel mixed models examined group differences, as well as age, sex and other effects, on frontal theta and frontal alpha asymmetry during both phases of the task and on performance accuracy and reaction times. Healthy adolescent girls exhibited lower frontal theta than both adolescent girls with BD and also adolescent boys with and without BD during reward anticipation and feedback. Across groups, adolescent boys displayed greater relative left frontal alpha activity than adolescent girls during reward anticipation and feedback. Behaviorally, adolescents with BD exhibited faster responses on both positively- and negatively-motivated trials versus neutral trials, whereas healthy adolescents had faster responses only on positively-motivated trials; adolescents with BD were less accurate in responding to neutral trials compared to healthy controls. These findings shed light on normative and BD-specific involvement of approach motivation and cognitive control during different stages of reward processing in adolescence and, further, provide evidence of adolescent sex differences in these processes.
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影响因子：
5.4
作者：
Goldstein BI;Birmaher B;Carlson GA;DelBello MP;Findling RL;Fristad M;Kowatch RA;Miklowitz DJ;Nery FG;Perez-Algorta G;Van Meter A;Zeni CP;Correll CU;Kim HW;Wozniak J;Chang KD;Hillegers M;Youngstrom EA
通讯作者：
Youngstrom EA
沿双极光谱的进展：从双极光谱条件转换为双极I和II疾病的纵向研究。
影响因子：
4.6
作者：
Alloy LB;Urošević S;Abramson LY;Jager-Hyman S;Nusslock R;Whitehouse WG;Hogan M
通讯作者：
Hogan M
影响因子：
3.7
作者：
Cragg, Lucy;Kovacevic, Natasa;Paus, Tomas
通讯作者：
Paus, Tomas
影响因子：
3.7
作者：
Atagun, M. I.;Guntekin, B.;Basar, E.
通讯作者：
Basar, E.
影响因子：
5.4
作者：
Beesdo, Katja;Hoefler, Michael;Pfennig, Andrea
通讯作者：
Pfennig, Andrea