Factors responsible for the emergence of arboviruses; strategies, challenges and limitations for their control.

Factors responsible for the emergence of arboviruses; strategies, challenges and limitations for their control.
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负责arboviruse出现的因素;其控制的策略,挑战和局限性。

DOI:
10.1038/emi.2015.18
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发表时间:
2015-03
影响因子:
13.2
通讯作者:
Gould, Ernest A.
Gould, Ernest A.
中科院分区:
医学2区
文献类型:
--
作者:
Liang, Guodong;Gao, Xiaoyan;Gould, Ernest A.
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在16至19世纪世纪,非洲人向美洲贩卖奴隶,导致新大陆首次出现两种节肢动物传播的病毒(虫媒病毒),黄热病病毒和登革热病毒。许多其他虫媒病毒已经从它们的森林水库中出现,并由于人类学行为、商业运输和土地整治等不断变化的因素而在全球范围内传播。在这里,我们概述了这些高度不同的虫媒病毒的一些特征,包括它们形成的各种生命周期以及它们适应栖息地和宿主可用性不断变化的机制。我们引用最近病毒出现的例子,说明虫媒病毒如何利用现代人类生活方式的后果。利用我们目前对这些病毒的了解,我们还试图证明在制定控制策略以减少未来新出现的虫媒病毒疾病的影响时遇到的一些限制。最后,我们提出了建议,由一个国际专家小组直接向世界卫生组织报告,旨在提供国际上可接受的准则,以改善新出现的虫媒病毒疾病的控制策略。这些目标的成功应该可以减轻近几十年来虫媒病毒从森林环境中出现时所遭受的痛苦和代价。
Slave trading of Africans to the Americas, during the 16th to the 19th century was responsible for the first recorded emergence in the New World of two arthropod-borne viruses (arboviruses), yellow fever virus and dengue virus. Many other arboviruses have since emerged from their sylvatic reservoirs and dispersed globally due to evolving factors that include anthropological behaviour, commercial transportation and land-remediation. Here, we outline some characteristics of these highly divergent arboviruses, including the variety of life cycles they have developed and the mechanisms by which they have adapted to evolving changes in habitat and host availability. We cite recent examples of virus emergence that exemplify how arboviruses have exploited the consequences of the modern human lifestyle. Using our current understanding of these viruses, we also attempt to demonstrate some of the limitations encountered in developing control strategies to reduce the impact of future emerging arbovirus diseases. Finally, we present recommendations for development by an international panel of experts reporting directly to World Health Organization, with the intention of providing internationally acceptable guidelines for improving emerging arbovirus disease control strategies. Success in these aims should alleviate the suffering and costs encountered during recent decades when arboviruses have emerged from their sylvatic environment.
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