Post-synaptic specialization of the neuromuscular junction: junctional folds formation, function, and disorders.
Post-synaptic specialization of the neuromuscular junction: junctional folds formation, function, and disorders.
复制标题
神经肌肉连接的突触后特化：连接折叠的形成、功能和紊乱。
DOI：
10.1186/s13578-022-00829-z
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发表时间：
2022-06-19
影响因子：
7.5
通讯作者：
Pan, Bing-Xing
中科院分区：
文献类型：
--
作者：
Zou, Suqi;Pan, Bing-Xing
关键词：
突触后特化对神经递质的释放和动作电位的传导至关重要。神经肌肉接头（NMJ）是运动神经元和肌肉细胞之间的突触，并且具有比中枢神经系统（CNS）中的突触更特化的突触后膜。NMJ内的肌膜折叠形成内陷部分，称为连接褶皱（JFs），它们在维持突触后膜结构中起重要作用。NMJ的形成和乙酰胆碱受体（AChR）聚集信号通路已被广泛研究和综述。虽然JFs被认为与维持神经递质释放的安全系数有关，但JFs的形成机制和功能尚不清楚。本文就JF的进化、形成、功能和疾病等方面作一综述。期望了解他们来自哪里，以及我们将来将在哪里学习。
Post-synaptic specialization is critical to the neurotransmitter release and action potential conduction. The neuromuscular junctions (NMJs) are the synapses between the motor neurons and muscle cells and have a more specialized post-synaptic membrane than synapses in the central nervous system (CNS). The sarcolemma within NMJ folded to form some invagination portions called junctional folds (JFs), and they have important roles in maintaining the post-synaptic membrane structure. The NMJ formation and the acetylcholine receptor (AChR) clustering signal pathway have been extensively studied and reviewed. Although it has been suggested that JFs are related to maintaining the safety factor of neurotransmitter release, the formation mechanism and function of JFs are still unclear. This review will focus on the JFs about evolution, formation, function, and disorders. Anticipate understanding of where they are coming from and where we will study in the future.
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