Investigating the zoonotic origin of the West African Ebola epidemic.
Investigating the zoonotic origin of the West African Ebola epidemic.
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DOI:
10.15252/emmm.201404792
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发表时间:
2015-01
影响因子:
11.1
通讯作者:
Leendertz FH
中科院分区:
文献类型:
--
作者:
Marí Saéz A;Weiss S;Nowak K;Lapeyre V;Zimmermann F;Düx A;Kühl HS;Kaba M;Regnaut S;Merkel K;Sachse A;Thiesen U;Villányi L;Boesch C;Dabrowski PW;Radonić A;Nitsche A;Leendertz SA;Petterson S;Becker S;Krähling V;Couacy-Hymann E;Akoua-Koffi C;Weber N;Schaade L;Fahr J;Borchert M;Gogarten JF;Calvignac-Spencer S;Leendertz FH
The severe Ebola virus disease epidemic occurring in West Africa stems from a single zoonotic transmission event to a 2-year-old boy in Meliandou, Guinea. We investigated the zoonotic origins of the epidemic using wildlife surveys, interviews, and molecular analyses of bat and environmental samples. We found no evidence for a concurrent outbreak in larger wildlife. Exposure to fruit bats is common in the region, but the index case may have been infected by playing in a hollow tree housing a colony of insectivorous free-tailed bats (Mops condylurus). Bats in this family have previously been discussed as potential sources for Ebola virus outbreaks, and experimental data have shown that this species can survive experimental infection. These analyses expand the range of possible Ebola virus sources to include insectivorous bats and reiterate the importance of broader sampling efforts for understanding Ebola virus ecology.
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影响因子:
5.9
作者:
Hicks, Thurston C.;Tranquilli, Sandra;Menken, Steph B. J.
通讯作者:
Menken, Steph B. J.
影响因子:
4.9
作者:
Calvignac-Spencer, Sebastien;Merkel, Kevin;Leendertz, Fabian H.
通讯作者:
Leendertz, Fabian H.
影响因子:
3.7
作者:
Pourrut, Xavier;Souris, Marc;Leroy, Eric
通讯作者:
Leroy, Eric
DOI:
10.1126/science.1259657
发表时间:
2014-09-12
期刊:
Science (New York, N.Y.)
影响因子:
--
作者:
Gire SK;Goba A;Andersen KG;Sealfon RS;Park DJ;Kanneh L;Jalloh S;Momoh M;Fullah M;Dudas G;Wohl S;Moses LM;Yozwiak NL;Winnicki S;Matranga CB;Malboeuf CM;Qu J;Gladden AD;Schaffner SF;Yang X;Jiang PP;Nekoui M;Colubri A;Coomber MR;Fonnie M;Moigboi A;Gbakie M;Kamara FK;Tucker V;Konuwa E;Saffa S;Sellu J;Jalloh AA;Kovoma A;Koninga J;Mustapha I;Kargbo K;Foday M;Yillah M;Kanneh F;Robert W;Massally JL;Chapman SB;Bochicchio J;Murphy C;Nusbaum C;Young S;Birren BW;Grant DS;Scheiffelin JS;Lander ES;Happi C;Gevao SM;Gnirke A;Rambaut A;Garry RF;Khan SH;Sabeti PC
通讯作者:
Sabeti PC
影响因子:
11.8
作者:
Swanepoel R;Leman PA;Burt FJ;Zachariades NA;Braack LE;Ksiazek TG;Rollin PE;Zaki SR;Peters CJ
通讯作者:
Peters CJ