The effect of computed tomography parameters on sarcopenia and myosteatosis assessment: a scoping review.

The effect of computed tomography parameters on sarcopenia and myosteatosis assessment: a scoping review.
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DOI:
10.1002/jcsm.13068
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发表时间:
2022-12
期刊:
Journal of cachexia, sarcopenia and muscle
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中科院分区:
其他
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计算机断层扫描(CT)是一种有价值的评估方法,肌肉病理,如肌肉减少症,恶病质,和肌肉脂肪变性。然而,几个关键的未被充分认识的扫描成像参数需要考虑的研究和临床使用,特别是CT千伏和造影剂的使用。我们进行了一项范围审查,以评估这些对CT肌肉测量的影响。我们回顾了1970年至2020年PubMed、Scopus和Web of Science中关于静脉造影剂和CT千伏变化对肌肉质量和密度的影响的文章。我们确定了971篇关于造影剂的文章和277篇关于千伏的文章。符合造影剂和千伏纳入标准的文章数量分别为11篇和7篇。10项研究评价了造影剂对肌肉密度的影响,其中9项研究发现造影剂显著增加CT肌肉密度(动脉期增加6-23%,静脉期增加19-57%,延迟期增加23-43%)。在评价造影剂对肌肉面积影响的10项研究中,有7项发现造影剂导致面积显著增加(≤2.58%)。六项评估千伏对肌肉密度的研究发现,较低的千伏导致较高的肌肉密度(增加14-40%)。一项研究报告称,降低千伏时肌肉面积显著减少(2.9%)。对比度和千伏变化的使用可能对骨骼肌分析产生显著影响,应在CT肌肉分析研究中予以考虑和报告。CT骨骼肌分析中的这些重要因素可能会改变临床和研究结果,因此除非得到更好的理解,否则会成为临床应用的障碍。
Computed tomography (CT) is a valuable assessment method for muscle pathologies such as sarcopenia, cachexia, and myosteatosis. However, several key underappreciated scan imaging parameters need consideration for both research and clinical use, specifically CT kilovoltage and the use of contrast material. We conducted a scoping review to assess these effects on CT muscle measures. We reviewed articles from PubMed, Scopus, and Web of Science from 1970 to 2020 on the effect of intravenous contrast material and variation in CT kilovoltage on muscle mass and density. We identified 971 articles on contrast and 277 articles on kilovoltage. The number of articles that met inclusion criteria for contrast and kilovoltage was 11 and 7, respectively. Ten studies evaluated the effect of contrast on muscle density of which nine found that contrast significantly increases CT muscle density (arterial phase 6–23% increase, venous phase 19–57% increase, and delayed phase 23–43% increase). Seven out of 10 studies evaluating the effect of contrast on muscle area found significant increases in area due to contrast (≤2.58%). Six studies evaluating kilovoltage on muscle density found that lower kilovoltage resulted in a higher muscle density (14–40% increase). One study reported a significant decrease in muscle area when reducing kilovoltage (2.9%). The use of contrast and kilovoltage variations can have dramatic effects on skeletal muscle analysis and should be considered and reported in CT muscle analysis research. These significant factors in CT skeletal muscle analysis can alter clinical and research outcomes and are therefore a barrier to clinical application unless better appreciated.
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