Astrocyte form and function in the developing central nervous system.
Astrocyte form and function in the developing central nervous system.
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DOI：
10.1016/j.spen.2013.10.003
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发表时间：
2013-12
影响因子：
2.7
通讯作者：
Deneen, Benjamin
中科院分区：
文献类型：
--
作者：
Chaboub, Lesley S.;Deneen, Benjamin
在我们探索大脑功能的过程中，星形胶质细胞一直被遗忘。在过去的几十年里，我们对中枢神经系统功能的了解呈指数级增长，因此星形胶质细胞已成为中枢神经系统生理学和疾病的关键人物。事实上，最近有几种小儿神经系统疾病与星形胶质细胞失调有关，包括脑白质营养不良、自闭症谱系障碍和癫痫。鉴于儿童疾病根植于发育过程，本综述的目的是对我们所知道的星形胶质细胞在发育中的中枢神经系统中的发育和功能进行分类。此外，我们将强调当前的挑战和问题，仍然在星形胶质细胞的发展领域。我们希望这篇综述将阐明星形胶质细胞及其相关的发育和生理功能作为治疗神经系统疾病的潜在治疗靶点的潜力。
Astrocytes have long been forgotten entities in our quest to understand brain function. Over the last few decades there has been an exponential increase in our knowledge of CNS function and consequently astrocytes have emerged as key figures in CNS physiology and disease. Indeed, several pediatric neurological disorders have recently been linked to astrocyte dysregulation including, leukodystrophies, autism spectrum disorders, and epilepsy. Given that pediatric disorders are rooted in developmental processes, the goal of this review is to catalog what we know about astrocyte development and function in the developing CNS. Moreover, we will highlight current challenges and questions that remain in the field of astrocyte development. Our hope is that this review will illuminate the potential of astrocytes and their associated developmental and physiological functions as potential therapeutic targets for the treatment of neurological disorders.
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DOI：
10.1590/s0100-879x1999000500016
发表时间：
1999-05-01
影响因子：
2.3
作者：
Gomes, FCA;Paulin, D;Neto, VM
通讯作者：
Neto, VM
影响因子：
16.2
作者：
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Deneen B
影响因子：
5.3
作者：
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通讯作者：
Ellisman, MH
影响因子：
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作者：
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通讯作者：
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影响因子：
64.8
作者：
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通讯作者：
Rothstein, Jeffrey D.