Reduced cortical thickness associated with visceral fat and BMI.
Reduced cortical thickness associated with visceral fat and BMI.
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DOI：
10.1016/j.nicl.2014.09.013
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Preissl H
中科院分区：
文献类型：
--
作者：
Veit R;Kullmann S;Heni M;Machann J;Häring HU;Fritsche A;Preissl H
脑结构成像研究表明，肥胖与灰质（GM）体积的广泛减少有关。虽然身体质量指数（BMI）是一个容易获得的人体测量指标，但实质性的健康问题更多地与特定的身体脂肪区室有关，如内脏脂肪组织（VAT）。我们研究了一组72名健康受试者（BMI范围20-35 kg/m2，年龄范围19-50岁）的皮质厚度测量。以VAT和BMI作为预测因素，年龄、性别、总表面积和教育程度作为混杂因素进行多元回归分析。BMI和VAT与左枕外侧区、左颞下皮质、左中央前区和顶下区皮质厚度的减少独立相关，而右枕叶、左梭状回和右颞下区仅与VAT呈负相关。此外，我们可以显示，随着VAT的增加，左颞叶皮质的厚度显著降低，并根据BMI进行调整。我们能够在与BMI和VAT相关的年轻至中年人群中检测到广泛的皮质变薄;这些发现与关注糖尿病患者GM体积差异的研究非常相似。这可能表明增值税相关不良反应（例如轻度炎症）的影响，对于有患糖尿病、代谢综合征和动脉硬化风险的个人来说，是对大脑完整性的潜在有害因素。我们调查了健康成人的皮质厚度。体重指数（BMI）和内脏脂肪组织（VAT）被用作预测因子。BMI和VAT与皮质厚度独立相关。随着VAT的增加，在颞叶皮质中观察到皮质变薄。我们的研究结果显示糖尿病患者GM体积差异的密切相似性。
Structural brain imaging studies have shown that obesity is associated with widespread reductions in gray matter (GM) volume. Although the body mass index (BMI) is an easily accessible anthropometric measure, substantial health problems are more related to specific body fat compartments, like visceral adipose tissue (VAT). We investigated cortical thickness measures in a group of 72 healthy subjects (BMI range 20–35 kg/m2, age range 19–50 years). Multiple regression analyses were performed using VAT and BMI as predictors and age, gender, total surface area and education as confounds. BMI and VAT were independently associated with reductions in cortical thickness in clusters comprising the left lateral occipital area, the left inferior temporal cortex, and the left precentral and inferior parietal area, while the right insula, the left fusiform gyrus and the right inferior temporal area showed a negative correlation with VAT only. In addition, we could show significant reductions in cortical thickness with increasing VAT adjusted for BMI in the left temporal cortex. We were able to detect widespread cortical thinning in a young to middle-aged population related to BMI and VAT; these findings show close resemblance to studies focusing on GM volume differences in diabetic patients. This may point to the influence of VAT related adverse effects, like low-grade inflammation, as a potentially harmful factor on brain integrity already in individuals at risk of developing diabetes, metabolic syndromes and arteriosclerosis. We investigated cortical thickness in healthy adults. Body mass index (BMI) and visceral adipose tissue (VAT) were used as predictors. BMI and VAT were independently associated with cortical thickness. Cortical thinning was observed in the temporal cortex with increasing VAT. Our findings show close resemblance to GM volume differences in diabetic patients.
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影响因子：
5.7
作者：
Jiao, Yun;Chen, Rong;Ke, Xiaoyan;Chu, Kangkang;Lu, Zuhong;Herskovits, Edward H.
通讯作者：
Herskovits, Edward H.
影响因子：
2.9
作者：
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影响因子：
4.4
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通讯作者：
Schick, F
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
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Sereno, MI
影响因子：
4.9
作者：
Aronson, D;Bartha, P;Levy, Y
通讯作者：
Levy, Y