Brain Network Response to Acupuncture Stimuli in Experimental Acute Low Back Pain: An fMRI Study.
Brain Network Response to Acupuncture Stimuli in Experimental Acute Low Back Pain: An fMRI Study.
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实验性急性腰痛中脑网络对针灸刺激的反应：一项功能磁共振成像研究
DOI：
10.1155/2015/210120
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Wu W
中科院分区：
文献类型：
--
作者：
Shi Y;Liu Z;Zhang S;Li Q;Guo S;Yang J;Wu W
大多数神经影像学研究表明，针灸可以显着调节健康受试者的大脑激活模式，而只有少数研究检查了临床疼痛。在本研究中，我们结合实验性急性腰痛（ALBP）模型和功能磁共振成像（fMRI）来探索针刺镇痛的神经机制。所有 ALBP 受试者首先在基线和疼痛发作期间接受两次静息态 fMRI 扫描，然后在 BL40 穴位伪随机地接受两次额外的 fMRI 扫描，一次在针刺刺激 (ACUP) 期间，一次在触觉刺激 (SHAM) 期间。我们的结果表明，与基线相比，疼痛状态在疼痛矩阵、边缘系统和默认模式网络（DMN）中具有较高的区域同质性（ReHo）值，而在额回和颞回中具有较低的ReHo值；与关闭状态相比，ACUP 在受试者中产生了广泛的失活，包括几乎所有边缘系统、疼痛状态和 DMN，并且还引起了注意力和体感系统的大量激活；与 SHAM 相比，我们发现 ACUP 在受试者中引起更多的失活和更少的激活。多个大脑网络在针灸镇痛中发挥着至关重要的作用，这表明 ACUP 优于体感引导的 ALBP 身心疗法。
Most neuroimaging studies have demonstrated that acupuncture can significantly modulate brain activation patterns in healthy subjects, while only a few studies have examined clinical pain. In the current study, we combined an experimental acute low back pain (ALBP) model and functional magnetic resonance imaging (fMRI) to explore the neural mechanisms of acupuncture analgesia. All ALBP subjects first underwent two resting state fMRI scans at baseline and during a painful episode and then underwent two additional fMRI scans, once during acupuncture stimulation (ACUP) and once during tactile stimulation (SHAM) pseudorandomly, at the BL40 acupoint. Our results showed that, compared with the baseline, the pain state had higher regional homogeneity (ReHo) values in the pain matrix, limbic system, and default mode network (DMN) and lower ReHo values in frontal gyrus and temporal gyrus; compared with the OFF status, ACUP yielded broad deactivation in subjects, including nearly all of the limbic system, pain status, and DMN, and also evoked numerous activations in the attentional and somatosensory systems; compared with SHAM, we found that ACUP induced more deactivations and fewer activations in the subjects. Multiple brain networks play crucial roles in acupuncture analgesia, suggesting that ACUP exceeds a somatosensory-guided mind-body therapy for ALBP.
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