AMDV Vaccine: Challenges and Perspectives.
AMDV Vaccine: Challenges and Perspectives.
复制标题
AMDV疫苗：挑战和前景。
DOI：
10.3390/v13091833
复制
发表时间：
2021-09-14
期刊：
影响因子：
--
通讯作者：
Abrahamyan L
中科院分区：
文献类型：
--
作者：
Markarian NM;Abrahamyan L
已知阿留申水貂病病毒（AMDV）是水貂工业中最重要的疾病。它在全球广泛传播，表现为致命的浆细胞病和高球蛋白血症。到目前为止，控制病毒传播的措施仅限于对amdv阳性水貂进行人工血清学检测。此外，由于这种病毒的持久性，根除阿留申病（AD）的努力基本上失败了。因此，有效控制病毒传播的策略对野生动物保护至关重要。对抗这种疾病的一个潜在关键工具是对水貂进行抗AMDV免疫。多年来，一些研究人员试图开发AMDV疫苗，并证明这些疫苗对水貂具有不同程度的保护作用。尽管进行了这些努力，但目前没有针对AMDV的疫苗，这使得阿留申疾病继续传播。在此，我们总结了之前在水貂中进行的AMDV免疫尝试以及其他预防措施，目的是为未来设计这种潜在的重要预防工具来对抗阿留申病的研究提供启示。
Aleutian mink disease virus (AMDV) is known to cause the most significant disease in the mink industry. It is globally widespread and manifested as a deadly plasmacytosis and hyperglobulinemia. So far, measures to control the viral spread have been limited to manual serological testing for AMDV-positive mink. Further, due to the persistent nature of this virus, attempts to eradicate Aleutian disease (AD) have largely failed. Therefore, effective strategies to control the viral spread are of crucial importance for wildlife protection. One potentially key tool in the fight against this disease is by the immunization of mink against AMDV. Throughout many years, several researchers have tried to develop AMDV vaccines and demonstrated varying degrees of protection in mink by those vaccines. Despite these attempts, there are currently no vaccines available against AMDV, allowing the continuation of the spread of Aleutian disease. Herein, we summarize previous AMDV immunization attempts in mink as well as other preventative measures with the purpose to shed light on future studies designing such a potentially crucial preventative tool against Aleutian disease.
登录
查看更多内容
影响因子：
7.3
作者：
Awate S;Babiuk LA;Mutwiri G
通讯作者：
Mutwiri G
影响因子：
2.6
作者：
Andersson, Anna-Maria;Nyman, Ann-Kristin;Wallgren, Per
通讯作者：
Wallgren, Per
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
影响因子：
5.4
作者：
BLOOM, ME;BERRY, BD;WOLFINBARGER, JB
通讯作者：
WOLFINBARGER, JB
DOI：
10.3390/v6072899
发表时间：
2014-07-23
期刊：
Viruses
影响因子：
--
作者：
Bilkova E;Forstova J;Abrahamyan L
通讯作者：
Abrahamyan L