Epidemiologic investigation of a family cluster of imported ZIKV cases in Guangdong, China: probable human-to-human transmission.
Epidemiologic investigation of a family cluster of imported ZIKV cases in Guangdong, China: probable human-to-human transmission.
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DOI：
10.1038/emi.2016.100
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发表时间：
2016-09-07
影响因子：
13.2
通讯作者：
Gong, Sitang
中科院分区：
文献类型：
--
作者：
Yin, Yingxian;Xu, Yi;Su, Ling;Zhu, Xun;Chen, Minxia;Zhu, Weijin;Xia, Huimin;Huang, Xi;Gong, Sitang
寨卡病毒是一种新出现的蚊媒黄病毒，可能会威胁到南方中国。一个从委内瑞拉返回中国的中国四口之家在机场出入境检查中首次发现小儿子发烧时，ZIKV呈阳性。他们在广东省恩平市当地一家医院被暂时分离，记录了他们的临床资料，并采集尿液和唾液分离ZIKV并获得病毒序列。除该名母亲外，所有患者均出现轻微皮疹和发烧症状。父亲、女儿和儿子的外膜基因序列完全相同。系统发育分析表明，该毒株与近几个月报告的几株进口毒株相似，这些毒株都聚集在一个从2015年巴西寨卡疫情中分离出来的群体中。结合委内瑞拉、纽约和广东2月份的气候特征，可以得出结论：我们的研究对象是来自委内瑞拉的输入病例。由于家庭成员之间共享相同的病毒序列，在这项研究中，不能排除直接人传人或媒介传播的可能性，但前者似乎更有可能。虽然我们的受试者患有轻微疾病，但流行病学家和公共卫生官员应该意识到当地合格媒介进一步扩大寨卡病毒传播的风险。
Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that can potentially threaten South China. A Chinese family of four returning from Venezuela to China was found to be positive for ZIKV when the youngest son's fever was first detected at an airport immigration inspection. They were isolated temporarily in a local hospital in Enping city, Guangdong province, where their clinical data were recorded and urine and saliva were collected to isolate ZIKV and to obtain viral sequences. All of them except the mother presented mild symptoms of rash and fever. Envelope gene sequences from the father, daughter and son were completely identical. Phylogenetic analysis demonstrated that this strain is similar to several imported strains reported in recent months, which are all clustered into a group isolated from 2015 ZIKA outbreaks in Brazil. Together with the climatic features in Venezuela, New York and Guangdong in February, it can be concluded that our subjects are imported cases from Venezuela. With the same viral sequence being shared between family members, neither direct human-to-human nor vector transmission can be ruled out in this study, but the former seems more likely. Although our subjects had mild illness, epidemiologists and public health officials should be aware of the risk of further expansion of ZIKV transmission by local competent vectors.
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