Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource.
Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource.
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DOI：
10.1002/hep.26744
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发表时间：
2014-01
期刊：
影响因子：
13.5
通讯作者：
Simmonds, Peter
中科院分区：
文献类型：
--
作者：
Smith, Donald B.;Bukh, Jens;Kuiken, Carla;Muerhoff, A. Scott;Rice, Charles M.;Stapleton, Jack T.;Simmonds, Peter
2005年关于丙型肝炎病毒（HCV）分类的共识提案为HCV变异体提供了一个商定的统一命名法，以及将其分配为基因型和亚型的标准。自其发表以来，通过核苷酸测序技术的进步以及对HCV遗传变异在疾病和治疗结果中的作用的日益关注，HCV序列的可用数据集已经大大扩展。目前的研究代表了对以前的共识HCV分类的重大更新，纳入了来自2013年5月公共数据库中超过1，300个（接近）完整的HCV基因组序列的额外序列信息。分析解决了基因型命名之间的几个命名冲突，并使用共识标准将HCV分类为7种确认的基因型和67种亚型。有21个额外的完整编码区序列的未分配的亚型。该研究还描述了由国际病毒分类委员会（ICTV）托管的网络资源的开发，该资源维护并定期更新参考分离株、登录号和注释比对表（http：//talk.ictvonline.org/links/hcv/hcv-classification.htm）。黄病毒科研究组敦促那些需要检查或提出新的HCV基因型或亚型的人在出版前与研究组联系，以避免文献中出现命名冲突。虽然分配基因型和亚型的标准与以前的共识提案保持不变，但在临时亚型的分配、“w”以外的亚型编号和基因型间重组的命名方面提出了变更。结论：这项研究代表了一个重要的参考点的共识分类的HCV变异，将有价值的研究人员在临床和基础科学领域的工作。（肝病学2014;59：318-327）
The 2005 consensus proposal for the classification of hepatitis C virus (HCV) presented an agreed and uniform nomenclature for HCV variants and the criteria for their assignment into genotypes and subtypes. Since its publication, the available dataset of HCV sequences has vastly expanded through advancement in nucleotide sequencing technologies and an increasing focus on the role of HCV genetic variation in disease and treatment outcomes. The current study represents a major update to the previous consensus HCV classification, incorporating additional sequence information derived from over 1,300 (near-)complete genome sequences of HCV available on public databases in May 2013. Analysis resolved several nomenclature conflicts between genotype designations and using consensus criteria created a classification of HCV into seven confirmed genotypes and 67 subtypes. There are 21 additional complete coding region sequences of unassigned subtype. The study additionally describes the development of a Web resource hosted by the International Committee for Taxonomy of Viruses (ICTV) that maintains and regularly updates tables of reference isolates, accession numbers, and annotated alignments (http://talk.ictvonline.org/links/hcv/hcv-classification.htm). The Flaviviridae Study Group urges those who need to check or propose new genotypes or subtypes of HCV to contact the Study Group in advance of publication to avoid nomenclature conflicts appearing in the literature. While the criteria for assigning genotypes and subtypes remain unchanged from previous consensus proposals, changes are proposed in the assignment of provisional subtypes, subtype numbering beyond “w,” and the nomenclature of intergenotypic recombinant. Conclusion: This study represents an important reference point for the consensus classification of HCV variants that will be of value to researchers working in clinical and basic science fields. (Hepatology 2014;59:318-327)
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EUHCVDB：欧洲丙型肝炎病毒数据库。
影响因子：
14.9
作者：
Combet, Christophe;Garnier, Nicolas;Charavay, Celine;Grando, Delphine;Crisan, Daniel;Lopez, Julien;Dehne-Garcia, Alexandre;Geourjon, Christophe;Bettler, Emmanuel;Hulo, Chantal;Le Mercier, Philippe;Bartenschlager, Ralf;Diepolder, Helmut;Moradpour, Darius;Pawlotsky, Jean-Michel;Rice, Charles M;Trepo, Christian;Penin, Francois;Deleage, Gilbert
通讯作者：
Deleage, Gilbert
DOI：
10.1073/pnas.90.17.8234
发表时间：
1993-09-01
影响因子：
11.1
作者：
BUKH, J;PURCELL, RH;MILLER, RH
通讯作者：
MILLER, RH
在中国393例肝病患者中，HCV分离株的多样性增加，代表六种基因型，12个亚型和两种新型基因型6变异。
影响因子：
8.8
作者：
Gu, Lin;Tong, Wangxia;Yuan, Manqiong;Lu, Teng;Li, Chunhua;Lu, Ling
通讯作者：
Lu, Ling
影响因子：
3.8
作者：
Kalinina, O;Norder, H;Magnius, LO
通讯作者：
Magnius, LO
DOI：
10.1006/bbrc.1997.6902
发表时间：
1997-07-09
影响因子：
3.1
作者：
Chamberlain, RW;Adams, NJ;Elliott, RM
通讯作者：
Elliott, RM