Tuning the Size of Poly(lactic-co-glycolic Acid) (PLGA) Nanoparticles Fabricated by Nanoprecipitation.
Tuning the Size of Poly(lactic-co-glycolic Acid) (PLGA) Nanoparticles Fabricated by Nanoprecipitation.
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DOI：
10.1002/biot.201700203
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发表时间：
2018-01
影响因子：
4.7
通讯作者：
Zhang C
中科院分区：
文献类型：
--
作者：
Huang W;Zhang C
高分子纳米颗粒（PNPs）是一种很有前途的癌症药物载体。颗粒的大小对药物的装载、体内分布、外渗、肿瘤内扩散和细胞摄取具有重要影响，因此对药物传递机制的成功开发至关重要。然而，制造确定尺寸的pnp的方法尚未建立。本研究的目的是建立一种可用于制造具有控制尺寸的pnp的方法。我们系统地研究了影响纳米沉淀法制备的PNPs尺寸的因素。研究的因素包括聚合物浓度、有机溶剂、温度、水相离子强度、有机相注入速度、水相搅拌速度、针径和最终聚合物浓度。聚合物的浓度、有机溶剂的选择、温度和水相的离子强度对PNPs的尺寸有显著影响，而这些因素的影响可以归结为一个参数，即溶剂在水中的扩散系数Dpw。通过严格控制这四个参数，有可能制备出具有高度可预测性和理想尺寸且尺寸分布窄的纳米颗粒。
Polymeric nanoparticles (PNPs) are promising drug carriers in cancer treatment. Size of the particles has a significant impact on drug loading, in vivo distribution, extravasation, intratumor diffusion and cell uptake, and thus is critical for the successful development of a drug delivery regime. However, methods for manufacturing PNPs of defined size are yet to be established. The goal of this study is to establish a method that can be used to fabricate PNPs with controlled size. We systematically investigated the factors that could impact the size of PNPs fabricated by nano-precipitation. The factors studied include polymer concentration, organic solvent, temperature, aqueous phase ionic strength, organic phase injection rate, aqueous phase agitation rate, gauge of the needles and final polymer concentration. Polymer concentration, the choice of organic solvent, temperature, and the ionic strength of the aqueous phase were shown to have a significant impact on the size of PNPs, and the effect of these factors can be attributed to a single parameter, the diffusion coefficient of the solvent in water, Dpw. It is possible that by tightly control these four parameters, nanoparticles with highly predictable and desirable size with narrow size distribution can be fabricated.
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