Microfluidic preparation of polymer nanospheres.
Microfluidic preparation of polymer nanospheres.
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DOI：
10.1007/s11051-014-2626-5
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发表时间：
2014
影响因子：
2.5
通讯作者：
Edirisinghe, Mohan
中科院分区：
文献类型：
--
作者：
Kucuk, Israfil;Edirisinghe, Mohan
关键词：
在这项工作中，利用V型微流控连接制备了表面为药物黏附量身定做的固体聚合物纳米球。将生物相容的聚合物溶液通过微流控接头的两个通道注入，该微流体接头也同时通过另一个通道输送挥发性液体全氟己烷。用高速相机成像解释了纳米球产生的机理。聚合物浓度(5-50wt%)和进料流量(50-300mgL/min−1)是控制纳米球直径的重要参数。聚合物纳米球的直径在80-920 nm之间，多分散性指数为11-19%。用先进的显微镜对所制备的纳米球的内部结构和表面进行了研究，发现其表面存在细小的气孔和裂缝，可作为药物包埋的场所。本文的在线版本(doi：10.1007/s11051-0142626-5)包含补充材料，授权用户可以使用。
In this work, solid polymer nanospheres with their surface tailored for drug adhesion were prepared using a V-shaped microfluidic junction. The biocompatible polymer solutions were infused using two channels of the microfluidic junction which was also simultaneously fed with a volatile liquid, perfluorohexane using the other channel. The mechanism by which the nanospheres are generated is explained using high speed camera imaging. The polymer concentration (5–50 wt%) and flow rates of the feeds (50–300 µl min−1) were important parameters in controlling the nanosphere diameter. The diameter of the polymer nanospheres was found to be in the range of 80–920 nm with a polydispersity index of 11–19 %. The interior structure and surfaces of the nanospheres prepared were studied using advanced microscopy and showed the presence of fine pores and cracks on surface which can be used as drug entrapment locations. The online version of this article (doi:10.1007/s11051-014-2626-5) contains supplementary material, which is available to authorized users.
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