Developmental evidence for serial homology of the vertebrate jaw and gill arch skeleton.

Developmental evidence for serial homology of the vertebrate jaw and gill arch skeleton.
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DOI:
10.1038/ncomms2429
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发表时间:
2013
影响因子:
16.6
通讯作者:
--
中科院分区:
综合性期刊1区
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--
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Gegenbaur的颚-鳃弓序列同源性的经典假设被广泛引用,但仍然没有古生物学证据(例如一系列反映鳃弓逐步转变为颚的化石)或发育遗传学数据(例如下颌骨,舌骨和鳃弓内骨骼中的共同分子机制)的支持。在这里,我们表明,嵌套表达的DLX基因-“DLX代码”,指定上,下颌的身份在哺乳动物和硬骨鱼类-是一个原始的功能,下颌骨,舌骨和鳃弓的有颌脊椎动物。使用命运映射技术,我们表明,主要的背侧和腹侧内骨骼段的颌骨,舌骨和鳃弓的溜冰鞋Leucoraja erinacea来自分子等价的间充质结构域的组合DLX基因表达。我们的数据表明,脊椎动物的颌骨,舌骨和鳃弓软骨是系列同源,并通过一个共同的Dlx蓝图的背腹侧连续图案。
Gegenbaur’s classical hypothesis of jaw-gill arch serial homology is widely cited, but remains unsupported by either paleontological evidence (e.g. a series of fossils reflecting the stepwise transformation of a gill arch into a jaw) or developmental genetic data (e.g. shared molecular mechanisms underlying segment identity in the mandibular, hyoid and gill arch endoskeletons). Here we show that nested expression of Dlx genes – the “Dlx code” that specifies upper and lower jaw identity in mammals and teleosts – is a primitive feature of the mandibular, hyoid and gill arches of jawed vertebrates. Using fate-mapping techniques, we demonstrate that the principal dorsal and ventral endoskeletal segments of the jaw, hyoid and gill arches of the skate Leucoraja erinacea derive from molecularly equivalent mesenchymal domains of combinatorial Dlx gene expression. Our data suggest that vertebrate jaw, hyoid and gill arch cartilages are serially homologous, and were primitively patterned dorsoventrally by a common Dlx blueprint.
DOI: 10.1016/s0169-5347(97)01125-7
发表时间: 1997-10-01
影响因子: 16.8
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