Old World arenavirus infection interferes with the expression of functional alpha-dystroglycan in the host cell.
Old World arenavirus infection interferes with the expression of functional alpha-dystroglycan in the host cell.
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旧世界沙粒病毒感染干扰宿主细胞中功能性α-肌营养不良聚糖的表达。
DOI：
10.1091/mbc.e07-04-0374
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发表时间：
2007
影响因子：
3.3
通讯作者：
Kunz,Stefan
中科院分区：
文献类型：
--
作者：
Rojek,JillianM;Campbell,KevinP;Oldstone,MichaelBA;Kunz,Stefan
α-Dystroglycan (α-DG) is an important cellular receptor for extracellular matrix (ECM) proteins as well as the Old World arenaviruses lymphocytic choriomeningitis virus (LCMV) and the human pathogenic Lassa fever virus (LFV). SpecificO-glycosylation of α-DG is critical for its function as receptor for ECM proteins and arenaviruses. Here, we investigated the impact of arenavirus infection on α-DG expression. Infection with an immunosuppressive LCMV isolate caused a marked reduction in expression of functional α-DG without affecting biosynthesis of DG core protein or global cell surface glycoprotein expression. The effect was caused by the viral glycoprotein (GP), and it critically depended on α-DG binding affinity and GP maturation. An equivalent effect was observed with LFVGP. Viral GP was found to associate with a complex between DG and the glycosyltransferase LARGE in the Golgi. Overexpression of LARGE restored functional α-DG expression in infected cells. We provide evidence that virus-induced down-modulation of functional α-DG perturbs DG-mediated assembly of laminin at the cell surface, affecting normal cell–matrix interactions.
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雌二醇引起的兔黄体细胞孕激素产生以及胆固醇和胆固醇酯含量的变化。
DOI：
10.1016/0006-291x(83)91101-4
发表时间：
1983
影响因子：
3.1
作者：
Holt,JA;Schreiber,JR;Zirkin,BR
通讯作者：
Zirkin,BR
DOI：
10.1073/pnas.80.3.702
发表时间：
1983-02
影响因子：
11.1
作者：
C. Privalle;J. Crivello;C. Jefcoate
通讯作者：
C. Privalle;J. Crivello;C. Jefcoate
17β-雌二醇对兔子的类固醇生成作用：刺激黄体过早退化的黄体酮合成。
影响因子：
4.8
作者：
E. Bender;J. Miller;R. Possley;P. Keyes
通讯作者：
P. Keyes
胆固醇供应与黄体线粒体类固醇合成的关系。
影响因子：
4.8
作者：
M. Toaff;J. Strauss;G. Flickinger;S. Shattil
通讯作者：
S. Shattil
胆固醇侧链裂解的多肽激活剂。
影响因子：
2.1
作者：
Pedersen,RC
通讯作者：
Pedersen,RC