The prevalence of age-related macular degeneration and associated risk factors.
The prevalence of age-related macular degeneration and associated risk factors.
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DOI：
10.1001/archophthalmol.2010.92
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发表时间：
2010-06
影响因子：
--
通讯作者：
Klein, Barbara E. K.
中科院分区：
文献类型：
--
作者：
Klein, Ronald;Cruickshanks, Karen J.;Nash, Scott D.;Krantz, Elizabeth M.;Javier Nieto, F.;Huang, Guan H.;Pankow, James S.;Klein, Barbara E. K.
为了确定年龄相关性黄斑变性（AMD）的患病率，并检查视网膜黄斑变性、视网膜色素异常和早期AMD与年龄、性别和其他危险因素的关系，参与了海狸坝后代研究（BOSS）。使用威斯康辛年龄相关性黄斑病变分级系统，通过对数字彩色眼底图像进行分级，确定黄斑病变的各种特征和严重程度。早期AMD在3.4%的队列中存在，从21-34岁的2.4%到65岁及以上的9.8%不等。在多变量模型中（以比值比[OR]表示；95%可信区间[CI]），年龄（1.22 / 5岁；1.09,1.36）、男性（1.65;1.01,2.69）、吸烟年数多（1 ~ 10 vs 0,1.31; 0.75, 2.29; 11+ vs 0,1.67; 1.03, 2.73）、血清高密度脂蛋白胆固醇（每5 mg/dL 0.91; 0.83, 0.998）和听力障碍（2.28;1.41,3.71）与早期AMD相关。血压水平、体重指数、体力活动、重度饮酒史、白细胞计数、血细胞比容、血小板计数、血清总胆固醇或颈动脉内膜-内侧厚度与早期AMD无关。这些数据表明，早期AMD在55岁之前并不常见，但之后随着年龄的增长而增加。早期AMD与可改变的危险因素有关，如吸烟和血清高密度脂蛋白胆固醇。
To determine the prevalence of age-related macular degeneration (AMD) and examine relationships of retinal drusen, retinal pigmentary abnormalities and early AMD to age, sex and other risk factors in 2810 people 21-84 years of age, participating in the Beaver Dam Offspring Study (BOSS). The presence and severity of various characteristics of drusen and other lesions typical of AMD were determined by grading digital color fundus images using the Wisconsin Age-Related Maculopathy Grading System. Early AMD was present in 3.4% of the cohort and varied from 2.4% in those 21-34 years of age to 9.8% in those 65 years of age or older. In a multivariable model (expressed as Odds Ratio [OR]; 95% Confidence Interval [CI]), age (1.22 per 5 years of age; 1.09, 1.36), being male (1.65; 1.01, 2.69), more pack years smoked (1 to 10 vs 0, 1.31; 0.75, 2.29; 11+ vs 0, 1.67; 1.03, 2.73), higher serum HDL cholesterol (per 5 mg/dL 0.91; 0.83, 0.998), and hearing impairment (2.28; 1.41, 3.71) were associated with early AMD. There were no associations of blood pressure level, body mass index, physical activity, history of heavy drinking, white blood cell count, hematocrit, platelet count, serum total cholesterol, or carotid intimal-medial thickness with early AMD. These data indicate that early AMD is infrequent before age 55 years but increases with age thereafter. Early AMD is related to modifiable risk factors, e.g., smoking and serum HDL cholesterol.
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影响因子：
13.7
作者：
Klein, R;Klein, BEK;Jacobs, DR
通讯作者：
Jacobs, DR
影响因子：
13.7
作者：
Klein, Ronald;Klein, Barbara E. K.;Gangnon, Ronald E.
通讯作者：
Gangnon, Ronald E.
DOI：
10.1198/016214501750332749
发表时间：
2001-03-01
影响因子：
3.7
作者：
Gao, FY;Wahba, G;Klein, B
通讯作者：
Klein, B
影响因子：
--
作者：
Klein, R;Meuer, SM;Reinke, J
通讯作者：
Reinke, J
影响因子：
13.7
作者：
Klein, R;Klein, BEK;Palta, M
通讯作者：
Palta, M