Lower Oxytocin Levels Are Associated with Lower Bone Mineral Density and Less Favorable Hip Geometry in Hypopituitary Men.
Lower Oxytocin Levels Are Associated with Lower Bone Mineral Density and Less Favorable Hip Geometry in Hypopituitary Men.
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DOI：
10.1159/000506638
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发表时间：
2021
影响因子：
4.1
通讯作者：
Lawson EA
中科院分区：
文献类型：
--
作者：
Aulinas A;Guarda FJ;Yu EW;Haines MS;Asanza E;Silva L;Tritos NA;Verbalis J;Miller KK;Lawson EA
垂体功能低下患者有骨质流失的危险。下丘脑-垂体后叶激素催产素和抗利尿激素分别对骨骼起合成代谢和分解代谢作用。垂体功能低下患者可能存在催产素缺乏的风险。催产素和/或抗利尿激素是否导致垂体功能低下患者骨稳态受损尚不清楚。探讨伴有（CDI）或不伴有（APD）中枢性尿崩症的垂体前叶缺乏患者血浆催产素和加压素水平与骨特征[骨矿物质密度（BMD）和髋关节结构分析（HSA）]的关系。横断面研究。男性37例（CDI 17例，APD 20例），年龄20 ~ 60岁。主要观察指标为空腹血浆催产素和抗利尿激素水平，以及双x线骨密度和HSA。平均BMD和HSA变量在CDI组和APD组之间没有差异。那些空腹催产素水平低于中位数的参与者，在大多数部位的平均BMD z分数都较低。空腹催产素水平与(1)CDI参与者脊柱、股骨颈、全髋和小全身的BMD z -评分呈正相关，(2)CDI参与者转子间区域有利的髋关节几何形状和力量变量，但APD参与者没有。在CDI组和ADP组中，抗利尿激素水平和骨骼变量之间没有关联。本研究为CDI垂体功能低下患者的催产素水平与骨密度、髋关节几何形状和强度之间的关系提供了证据。未来的研究对于确定催产素是否可以用于治疗垂体功能低下患者的骨骼健康将是重要的。
Hypopituitary patients are at risk for bone loss. Hypothalamic-posterior pituitary hormones oxytocin and vasopressin are anabolic and catabolic, respectively, to the skeleton. Patients with hypopituitarism may be at risk for oxytocin deficiency. Whether oxytocin and/or vasopressin contribute to impaired bone homeostasis in hypopituitarism is unknown. To determine the relationship between plasma oxytocin and vasopressin levels and bone characteristics [bone mineral density (BMD) and hip structural analysis (HSA)] in patients who have anterior pituitary deficiencies with (CDI) or without (APD) central diabetes insipidus. Cross-sectional study. Thirty-seven men (17 CDI and 20 APD), age 20-60 years. Main outcome measures were fasting plasma oxytocin and vasopressin levels, and BMD and HSA using dual x-ray absorptiometry. Mean BMD and HSA variables did not differ between the CDI and APD groups. Mean BMD Z-scores at most sites were lower in those participants who had fasting oxytocin levels below, than above, the median. There were positive associations between fasting oxytocin levels and (1) BMD Z-scores at the spine, femoral neck, total hip and subtotal body and (2) favorable hip geometry and strength variables at the intertrochanteric region in CDI, but not APD, participants. No associations between vasopressin levels and bone variables were observed within CDI or ADP groups. This study provides evidence for a relationship between oxytocin levels and BMD and estimated hip geometry and strength in hypopituitarism with CDI. Future studies will be important to determine whether oxytocin could be used therapeutically to optimize bone health in patients with hypopituitarism.
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DOI：
10.1016/s0006-291x(02)02009-0
发表时间：
2002-09-27
影响因子：
3.1
作者：
Colucci, S;Colaianni, G;Zallone, A
通讯作者：
Zallone, A
影响因子：
5.8
作者：
Elbornsson M;Götherström G;Bosæus I;Bengtsson BÅ;Johannsson G;Svensson J
通讯作者：
Svensson J
影响因子：
5.8
作者：
AMICO, JA;SEIF, SM;ROBINSON, AG
通讯作者：
ROBINSON, AG
影响因子：
7.1
作者：
MAZESS, RB;BARDEN, HS;HANSON, J
通讯作者：
HANSON, J
影响因子：
4
作者：
Breuil, V.;Fontas, E.;Szulc, P.
通讯作者：
Szulc, P.