Noninvasive Assessment of Retinal Blood Flow Using a Novel Handheld Laser Speckle Contrast Imager.
Noninvasive Assessment of Retinal Blood Flow Using a Novel Handheld Laser Speckle Contrast Imager.
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DOI：
10.1167/tvst.7.6.7
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发表时间：
2018-11
影响因子：
3
通讯作者：
Saeedi OJ
中科院分区：
文献类型：
--
作者：
Rege A;Cunningham SI;Liu Y;Raje K;Kalarn S;Brooke MJ;Schocket L;Scott S;Shafi A;Toledo L;Saeedi OJ
我们评估了手持式和稳定用例中新型手持式激光散斑成像仪的血流测量的图像质量和再现性。在手持稳定用例中，使用 XyCAM 手持式视网膜成像仪研究设备 (XyCAM HRI) 在九个连续成像过程中对 11 名散瞳人类受试者进行成像。然后受试者使用 Topcon TRC 50DX 进行标准彩色眼底摄影。将 XyCAM HRI 无红照片的血管与背景对比度与眼底照片进行比较，同时还确定了特定动脉和静脉中血流测量值的变异系数。与标准彩色眼底照片相比，手持使用情况下的血管与背景对比度在统计上更大（P = 0.01）。平均血流速度 (BFV) 的估计在稳定和手持用例之间高度相关 (r2 = 0.96)。动脉中的峰值速度估计值显着高于静脉中的峰值速度（P < 0.05）。 XyCAM HRI 原型可以获得与彩色眼底照片相同或更好清晰度的眼底照片，并在手持式用例中可重复地获取功能性血流信息。据我们所知，这是首次对手持式激光散斑视网膜成像设备进行人体研究。视网膜血流量的测定可应用于眼科和全身疾病，并且可在护理点广泛采用测定血流量的便携式手持式视网膜成像仪。
We assessed the image quality and reproducibility of blood flow measurements from a novel handheld laser speckle imager in handheld and stabilized use cases. Eleven dilated human subjects were imaged with the XyCAM Handheld Retinal Imager investigational device (XyCAM HRI) in the handheld and stabilized use case in nine consecutive imaging sessions. Subjects then underwent standard color fundus photography using a Topcon TRC 50DX. The vessel-to-background contrast of the XyCAM HRI red-free photo was compared to the fundus photograph, while the coefficient of variation of blood flow measurements in specific arteries and veins also was determined. Vessel-to-background contrast was statistically greater in the handheld use case when compared to the standard color fundus photographs (P = 0.01). Estimates of mean blood flow velocity (BFV) were highly correlated between the stabilized and handheld use case (r2 = 0.96). Peak velocity estimates in arteries were significantly higher than those in veins (P < 0.05). The XyCAM HRI prototype can acquire fundus photographs with the same or better level of clarity as color fundus photographs, and reproducibly acquire functional blood flow information in the handheld use case. To our knowledge, this is the first human study of a handheld laser speckle retinal imaging device. Determination of retinal blood flow has applications to ophthalmic and systemic disease and a portable handheld retinal imager that determines blood flow may be widely adopted at the point of care.
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DOI：
10.2147/opth.s22093
发表时间：
2011
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
Aizawa N;Yokoyama Y;Chiba N;Omodaka K;Yasuda M;Otomo T;Nakamura M;Fuse N;Nakazawa T
通讯作者：
Nakazawa T
影响因子：
3.4
作者：
Kurvinen, Leena;Kyto, Janne P.;Harju, Mika
通讯作者：
Harju, Mika
影响因子：
8.3
作者：
Ikram, MK;Witteman, JCM;de Jong, PTVM
通讯作者：
de Jong, PTVM
影响因子：
2
作者：
Burgansky-Eliash, Zvia;Bartov, Elisha;Gaton, Dan
通讯作者：
Gaton, Dan
影响因子：
3.5
作者：
Chen, Chieh-Li;Bojikian, Karine D.;Wang, Ruikang K.
通讯作者：
Wang, Ruikang K.