Precise protein post-translational modifications modulate ABI5 activity.

Precise protein post-translational modifications modulate ABI5 activity.
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精确的蛋白质翻译后修饰可调节 ABI5 活性。

DOI:
10.1016/j.tplants.2015.05.004
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发表时间:
2015-09
影响因子:
20.5
通讯作者:
Xie, Qi
Xie, Qi
中科院分区:
生物学1区
文献类型:
--
作者:
Yu, Feifei;Wu, Yaorong;Xie, Qi

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脱落酸不敏感5(Abscisic acid-insensitive 5,ABI 5)是一种植物碱性亮氨酸拉链(basic leucine zipper,bZIP)转录因子,在植物种子休眠、萌发、生长和开花等脱落酸(abscisic acid,阿坝)信号通路中起着重要的调控作用。最近,新的证据表明,不同的翻译后修饰(PTM)的组合可能共同控制ABI 5的稳定性和活性。在这篇综述中,我们强调了三种类型的PTM(蛋白磷酸化/去磷酸化,泛素化和sumoylation)和它们的相互作用,精确地调节ABI 5信号。ABI 5是阿坝信号通路中研究最多的关键分子,因此,这篇综述可以作为一个模型来指导其他植物激素信号通路中重要调节因子的翻译后研究。
Abscisic acid-insensitive 5 (ABI5), a plant basic leucine zipper (bZIP) transcription factor, has been revealed to be the key regulator in the abscisic acid (ABA) signaling pathway controlling seed dormancy, germination, plant growth, and flowering time. Recently, new evidence has come to light that a combination of different post-translational modifications (PTMs) might together control the stability and activity of ABI5. In this review, we highlight three types of PTM (protein phosphorylation/dephosphorylation, ubiquitination, and sumoylation) and their interactions that precisely regulate ABI5 signaling. ABI5 is the best-studied key molecule in the ABA signaling pathway with respect to PTMs; therefore, this review could serve as a model to guide post-translational studies of important regulators in other plant hormone signaling pathways.
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