Distinctive features of the central synaptic organization of Drosophila larval proprioceptors.
Distinctive features of the central synaptic organization of Drosophila larval proprioceptors.
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果蝇幼虫本体感受器中枢突触组织的独特特征。
DOI：
10.3389/fncir.2023.1223334
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发表时间：
2023
影响因子：
3.5
通讯作者：
中科院分区：
文献类型：
--
作者：
本体感觉反馈对于运动控制至关重要，但如何将这些信息纳入中央本体感觉处理电路仍然知之甚少。电路组织源自神经元之间突触连接的空间分布。在只能同时探测少数细胞的模型系统中很难辨别这种分布。因此，我们转向一个相对简单易懂的神经系统来思考：本体感受器的输入和输出突触在空间中是如何组织的，这种组织的原理是什么？使用果蝇幼虫连接组，我们生成了几个相邻身体节段（每个节段 5-6 个左右对）中 34 个本体感受器的输入和输出突触的图。我们描述了这些突触的空间组织，并将这种组织与其他体感神经元突触的空间组织进行了比较。我们发现幼虫本体感受器突触的三个显着特征：（1）一般来说，个体本体感受器类型表现出节段性体形。 (2)本体感受器输出突触在空间上既会聚又发散；它们被组织成六个空间域，每个域包含一组独特的一个或多个本体感受器。本体感受器沿着近端轴突进入神经毡的路径形成输出突触。 (3)本体感受器接收很少的抑制性输入突触。此外，我们发现这三个特征不适用于其他幼虫体感神经元。因此，我们生成了迄今为止最全面的本体感受器突触如何集中组织的图。该图记录了先前未描述的本体感受器的特征，提出了有关潜在发育机制的问题，并对下游本体感受处理电路产生了影响。
Proprioceptive feedback is critically needed for locomotor control, but how this information is incorporated into central proprioceptive processing circuits remains poorly understood. Circuit organization emerges from the spatial distribution of synaptic connections between neurons. This distribution is difficult to discern in model systems where only a few cells can be probed simultaneously. Therefore, we turned to a relatively simple and accessible nervous system to ask: how are proprioceptors’ input and output synapses organized in space, and what principles underlie this organization? Using the Drosophila larval connectome, we generated a map of the input and output synapses of 34 proprioceptors in several adjacent body segments (5–6 left-right pairs per segment). We characterized the spatial organization of these synapses, and compared this organization to that of other somatosensory neurons’ synapses. We found three distinguishing features of larval proprioceptor synapses: (1) Generally, individual proprioceptor types display segmental somatotopy. (2) Proprioceptor output synapses both converge and diverge in space; they are organized into six spatial domains, each containing a unique set of one or more proprioceptors. Proprioceptors form output synapses along the proximal axonal entry pathway into the neuropil. (3) Proprioceptors receive few inhibitory input synapses. Further, we find that these three features do not apply to other larval somatosensory neurons. Thus, we have generated the most comprehensive map to date of how proprioceptor synapses are centrally organized. This map documents previously undescribed features of proprioceptors, raises questions about underlying developmental mechanisms, and has implications for downstream proprioceptive processing circuits.
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DOI：
10.1016/j.cub.2021.09.035
发表时间：
2021-12-06
期刊：
Current biology : CB
影响因子：
--
作者：
Chen C;Agrawal S;Mark B;Mamiya A;Sustar A;Phelps JS;Lee WA;Dickson BJ;Card GM;Tuthill JC
通讯作者：
Tuthill JC
DOI：
10.1073/pnas.1419045111
发表时间：
2014-11-25
影响因子：
11.1
作者：
Akay, Turgay;Tourtellotte, Warren G.;Jessell, Thomas M.
通讯作者：
Jessell, Thomas M.
DOI：
10.1007/bf00604897
发表时间：
1988-01-01
影响因子：
2.1
作者：
BURROWS, M;PFLUGER, HJ
通讯作者：
PFLUGER, HJ
影响因子：
5.5
作者：
EDGLEY, SA;JANKOWSKA, E
通讯作者：
JANKOWSKA, E
影响因子：
5.5
作者：
BROWN, AG;FYFFE, REW
通讯作者：
FYFFE, REW