Sensory Circuit Remodeling and Movement Recovery After Spinal Cord Injury.

Sensory Circuit Remodeling and Movement Recovery After Spinal Cord Injury.
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脊髓损伤后感觉回路重塑与运动恢复。

DOI:
10.3389/fnins.2021.787690
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发表时间:
2021
影响因子:
4.3
通讯作者:
Hollis ER
Hollis ER
中科院分区:
医学2区
文献类型:
--
作者:
Moreno-López Y;Hollis ER

文献摘要

参考文献

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脊髓损伤(SCI)后感觉回路功能的恢复对运动恢复至关重要,但目前的干预措施主要针对运动通路。被脊髓损伤破坏的皮质感觉运动网络是感知、塑造和执行运动的关键。初级感觉皮质(S1)和运动皮质(M1)之间的皮质连接是学习和损伤反应中功能可塑性的关键位点。脊髓损伤后,在运动皮层,皮质回路发生动态重塑;然而,尚不清楚康复如何塑造S1-M1网络的可塑性,或者这些变化如何影响运动恢复。
Restoring sensory circuit function after spinal cord injury (SCI) is essential for recovery of movement, yet current interventions predominantly target motor pathways. Integrated cortical sensorimotor networks, disrupted by SCI, are critical for perceiving, shaping, and executing movement. Corticocortical connections between primary sensory (S1) and motor (M1) cortices are critical loci of functional plasticity in response to learning and injury. Following SCI, in the motor cortex, corticocortical circuits undergo dynamic remodeling; however, it remains unknown how rehabilitation shapes the plasticity of S1-M1 networks or how these changes may impact recovery of movement.
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