Usefulness of routine periodic fasting to lower risk of coronary artery disease in patients undergoing coronary angiography.
Usefulness of routine periodic fasting to lower risk of coronary artery disease in patients undergoing coronary angiography.
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DOI：
10.1016/j.amjcard.2008.05.021
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发表时间：
2008-10-01
影响因子：
2.8
通讯作者：
Muhlestein, Joseph B.
中科院分区：
文献类型：
--
作者：
Home, Benjamin D.;May, Heidi T.;Anderson, Jeffrey L.;Kfoury, Abdallah G.;Bailey, Beau M.;McClure, Brian S.;Renlund, Dale G.;Lappe, Donald L.;Carlquist, John F.;Fisher, Patrick W.;Pearson, Robert R.;Bair, Tami L.;Adams, Ted D.;Muhlestein, Joseph B.
冠状动脉疾病（CAD）是一种常见的多因素疾病。犹他州耶稣基督后期圣徒教会（LDS，或摩门教徒）的成员可能比其他犹他州和美国人口的心脏病死亡率低。虽然LDS禁止吸烟可能有助于降低心脏病风险，但尚不清楚其他共同行为是否也有贡献。本研究评估了禁食的潜在CAD相关影响。对1994-2002年入选Intermountain Heart Collaborative Study登记研究的患者（N1= 4，629）进行了宗教偏好与CAD诊断（血管造影显示冠状动脉狭窄≥70%）或无CAD（冠状动脉正常，狭窄<10%）的相关性评价。因此，另一组患者（N2=448）被调查（2004-2006）行为因素与CAD的关联，主要变量是常规禁食（即，饮食禁忌）。二次调查措施包括禁止酒精，茶和咖啡，社会支持和宗教崇拜模式。在人群1（初始）中，61%的LDS和66%的所有其他患者患有CAD（校正[包括吸烟]：比值比[OR]=0.81; p=0.009）。在人群2（调查）中，空腹与较低的CAD风险相关（64% vs. 76% CAD; OR=0.55，CI=0.35，0.87; p=0.010），并且在调整传统风险因素后仍然如此（OR=0.46，CI=0.27，0.81; p=0.007）。空腹也与较低的糖尿病患病率相关（p=0.048）。在进入其他次要行为指标的回归模型中，禁食仍然具有显著性，效应量相似。总之，不仅禁止吸烟，而且定期禁食与降低CAD风险相关。
Coronary artery disease (CAD) is common and multi-factorial. Members of the Church of Jesus Christ of Latter-day Saints (LDS, or Mormons) in Utah may have lower cardiac mortality than other Utahns and the US population. While the LDS proscription of smoking likely contributes to lower cardiac risk, it is unknown whether other shared behaviors also contribute. This study evaluated potential CAD-associated effects of fasting. Patients (N1=4,629) enrolled in the Intermountain Heart Collaborative Study registry (1994-2002) were evaluated for association of religious preference with CAD diagnosis (≥70% coronary stenosis on angiography) or no CAD (normal coronaries, <10% stenosis). Consequently, another set of patients (N2=448) were surveyed (2004-2006) for association of behavioral factors with CAD, with the primary variable being routine fasting (i.e., abstinence from food and drink). Secondary survey measures included proscription of alcohol, tea, and coffee, social support, and religious worship patterns. In population 1 (initial), 61% of LDS and 66% of all others had CAD (adjusted [including for smoking]: odds ratio [OR]=0.81; p=0.009). In population 2 (survey), fasting was associated with lower risk of CAD (64% vs. 76% CAD; OR=0.55, CI=0.35, 0.87; p=0.010) and this remained after adjustment for traditional risk factors (OR=0.46, CI=0.27, 0.81; p=0.007). Fasting was also associated with lower diabetes prevalence (p=0.048). In regression models entering other secondary behavioral measures, fasting remained significant with similar effect size. In conclusion, not only proscription of tobacco, but also routine periodic fasting was associated with lower risk of CAD.
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影响因子：
5
作者：
LYON, JL;WETZLER, HP;WILLIAMS, RR
通讯作者：
WILLIAMS, RR
影响因子：
--
作者：
Mortensen, EL;Jensen, HH;Reinisch, JM
通讯作者：
Reinisch, JM
DOI：
10.1073/pnas.0308291101
发表时间：
2004-04-27
影响因子：
11.1
作者：
Fontana, L;Meyer, TE;Holloszy, JO
通讯作者：
Holloszy, JO
影响因子：
7.7
作者：
Rustenbeck, I;Wienbergen, A;Jörns, A
通讯作者：
Jörns, A
影响因子：
37.8
作者：
Lopez-Garcia, E;van Dam, RM;Hu, FB
通讯作者：
Hu, FB